دانلود رایگان مقاله لاتین تنظیم بازوفیل از سایت الزویر
عنوان فارسی مقاله:
تنظیم بازوفیل و توسعه ماست سل توسط عوامل رونویسی
عنوان انگلیسی مقاله:
Regulation of basophil and mast cell development by transcription factors
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Basophils and mast cells are important effector cells that contribute to host defense against parasitic infections and to allergic responses.1e3 Basophils and mast cells express highaffinity immunoglobulin E (IgE) receptor (FcεRI) on their surfaces. Cross-linking of FcεRI by antigen stimulation causes the release of inflammatory cytokines and chemical mediators.2,4 While basophils and mast cells have many similarities, they also have distinct characteristics.3,5 Mast cells reside mainly in tissues and are barely detected in blood. However, basophils circulate in blood and migrate to tissues in response to stimuli. In addition, mast cells have a life span of several weeks to months, whereas basophils survive approximately 60 h. Nuclear morphology and expression of several surface receptors also differ between basophils and mast cells. Consequently, they possess non-redundant functions, although these distinctions are not described in detail here. In recent years, basophil and mast cell development has been an active area of research, resulting in the identification of various progenitors and transcription factors that regulate their development. This review presents an outline of the mechanisms of developmental regulation of basophils and mast cells, based on currently available information.
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کلمات کلیدی:
Transcription factor IRF8 plays a critical role in the development of ... www.bloodjournal.org/content/125/2/358 by H Sasaki - 2015 - Cited by 20 - Related articles Furthermore, we demonstrate that GATA2, a transcription factor known to promote basophil and mast cell differentiation, acts downstream of IRF8. These results ... A role of the transcription factor IRF8 in basophil and mast cell ... www.exphem.org/article/S0301-472X(15)00455-5/abstract by H Sasaki - 2015 A role of the transcription factor IRF8 in basophil and mast cell development ... stem cells differentiate into basophil progenitors (BaPs) and mast cell progenitors ... Figure 2 | Development of mast cells and basophils in the ... - Nature www.nature.com › Journal home › Archive › Review › Full text FIGURE 2 | Development of mast cells and basophils in the murine bone marrow. ... Transcription factors (shown in blue) and cytokines (shown in red) that drive ... The order of expression of transcription factors directs hierarchical ... genesdev.cshlp.org/content/20/21/3010.long by H Iwasaki - 2006 - Cited by 229 - Related articles Eosinophils, basophils, and mast cells are multifunctional hematopoietic effectors that ... Expression profiles of transcription factors and lineage-related genes in ... 1997), and found that these cell types develop along the myeloid lineage ... Signal Transduction in Mast Cells and Basophils https://books.google.com/books?isbn=1461221544 Ehud Razin, Juan Rivera - 2012 - Science ... in murine mast cell line CPII, 241 Mast cell growth factor (MGF), 12 Mast cell lines ... development by IL-3, 17–18 distinguishing from basophils, 55 exocytosis of, ... in mi/mimice, 34–35 Microphthalmia transcription factor (mi), in mast cells, ...
