دانلود رایگان مقاله لاتین تغییر روند پیری از سایت الزویر
عنوان فارسی مقاله:
تغییر روند پیری با هیپوکامپ و قشر سکرتاز فعالیت های موش صحرایی ویستار
عنوان انگلیسی مقاله:
Aging process alters hippocampal and cortical secretase activities of Wistar rats
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Aging process and age-related diseases are usually accompanied by cognitive decline and structural alterations in brain areas such as cortex and hippocampus [1–3]. Substantial data have shown that -amyloid (A) brain deposition, a 39 to 43 amino acid peptides derived from amyloid precursor protein (APP) is implicated in both Alzheimer disease (AD) and normal aging process [4–6]. Although amyloid plaques have been found in aged human brain [7,8] little attention has been given to APP processing machinery during the healthy aging process. APP can be proteolytically cleaved by amyloidogenic or nonamyloidogenic pathways. The amyloidogenic pathway comprises the sequential APP cleavages by -secretase and -secretase leading to A production [9,10]; -secretase activity is represented by BACE (-site APP-cleaving enzyme-1) [11]. There are paradoxical findings about the relationship between A and cognitive performance since A has demonstrated a dual neuromodulatory effect, which can improve or impair memory performance [12–15]. Moreover, recentin vivo imaging studies have failed to find any correlations between cognitive performance and amyloid deposition [16]. Taken together, we can suggest that in fact APP processing machinery rather than the A levels is related to cognitive performance during the aging process. The non-amyloidogenic APP processing pathway is represented by –secretases. Themembers of a Disintegrin andMetalloprotease (ADAM) family, such as tumor necrosis factor (TNF)- converting enzyme (TACE or ADAM17) and ADAM10 have –secretase activity and generate -APPs that play a role in synaptic plasticity, neuroprotection and synaptogenesis [17,18]. Although sAPP levels are reduced in cerebrospinal fluid (CSF) of 23-month-old rats [19], to the best of our knowledge, there are no studies evaluating the nonamyloidogenic pathway role such as TACE activity during normal brain aging process. However, increased TACE activity and consequently higher sAPP levels may be related to neurotrophic effects as synaptic formation and cognitive improvement [17,20]. A significant body of clinical and experimental evidences has indicated that regular physical exercise improves cognitive functions during normal aging and age-associated disorders [21–24]. The effects of forced and voluntary exercise protocols on A- associated neuropathology and APP pathways processing have been investigated [25–29]. Recently, Zhao et al. [30] demonstrated that forced treadmill exercise ameliorates the spatial memory impairment accompanied by alterations in hippocampal plaques in APP/PS1 mice. In accordance, this transgenic model subjected to a voluntary exercise had improved memory, lower A aggregation and BACE activity in hippocampus and cortex [31]. Despite these findings demonstrating that exercise can modulate secretase activities in AD models little is known regarding the relationship between APP processing and exercise effects during the healthy aging process. Previously, w
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کلمات کلیدی:
Cell Research - Figures and tables for article: A GPCR/secretase ... www.nature.com › Journal home › Archive › Original Articles › Full text DOR activation specifically enhances BACE1 and γ-secretase activities for .... Detergent extracts from hippocampus or cortex of the mice were prepared and ... Aging process alters hippocampal and cortical secretase activities of ... www.alzforum.org/.../aging-process-alters-hippocampal-and-cortical-secretase-activiti... Aging process alters hippocampal and cortical secretase activities of Wistar rats. Behav Brain Res. 2017 Jan 15;317:374-381. Epub 2016 Oct 1 PubMed. APP processing in Alzheimer's disease | Molecular Brain | Full Text https://molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-4-3 by Y Zhang - 2011 - Cited by 327 - Related articles Jan 7, 2011 - In vulnerable brain regions, such as the hippocampus and cortex, there .... inhibitor prevented regulated α-secretase activity in human neurons ... Handbook of Neurochemistry and Molecular Neurobiology: Development ... https://books.google.com/books?isbn=0387326707 Abel Lajtha, Regino Perez-Polo, Steffen Roßner - 2008 - Medical Therefore, it was believed for a long time that the β-secretase crucial for Aβ generation ... As expected, BACE1 expression is robust in neocortical and hippocampal brain ... Interestingly, when plotting cortical α- or β-secretase activities against ... Selenomethionine reduces the deposition of beta-amyloid plaques by ... pubs.rsc.org/en/content/articlehtml/2016/MT/C6MT00117C by ZH Zhang - 2016 - Cited by 1 - Related articles Jul 22, 2016 - ... of β-secretase levels and enhanced activity of selenoenzymes as well as increased levels of Se in the hippocampus and cortex. Se-Met ... Functional Neurobiology of Aging - Page 394 - Google Books Result https://books.google.com/books?isbn=008052558X Patrick R. Hof, Charles V. Mobbs - 2001 - Science Interestingly, APP -secretase inhibitors also interfere with the processing of Notch .... decreased acetylcholinesterase activity in the cortex and hippocampus, and ...
