دانلود رایگان مقاله لاتین تضعیف کننده ایمنی پپتید گریزان از سایت الزویر
عنوان فارسی مقاله:
محلول سرکوبگر واکنش ایمنی (SIRS): ارزیابی مجدد تضعیف کننده ایمنی بالقوه یک پپتید گریزان
عنوان انگلیسی مقاله:
Soluble Immune Response Suppressor (SIRS): Reassessing the immunosuppressant potential of an elusive peptide
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The role of soluble substances (first called ‘factors,’ later lymphokines and finally cytokines) in the generation and regulation of immune responses was first proposed in the 1960s (for additional details see [1]) along with the two-signal hypothesis of lymphocyte activation [2,3]. In the early 1970s, Gershon and colleagues suggested that a unique class of T-cells, termed suppressor cells, could negatively regulate immune responses [4]. This coincided with the explosive growth of studies around soluble factors (lymphokines) regulating immunity as illustrated in a series of workshops [5–8]. The simultaneous improvement in analytical tools in molecular biology (cloning and DNA sequencing) and protein chemistry (HPLC and improved protein sequencing) in the 1970s and early 1980s foreshadowed the areas genomics and proteomics. These new tools allowed the purification of factors and the determination that many, but certainly not all, were protein in nature. Molecular cloning techniques developed in the late 1970s– early1980s allowed investigators to confirm that many of these factors came from genes expressed during immune responses and led to their sequence identity being determined [5–8]. During this time, limited progress was made in the unambiguous determination of the biochemical nature of suppressor factors. The author worked diligently on this problem along with many colleagues from 1975 to 1990 [9]. By the late 1980s with a few exceptions, little clarity had been reached either in terms of the precise biochemical composition of these suppressor factors or their genetic origins. Complicating this work was the question of whether such factors showed antigen specificity (i.e. were antigen specific suppressor factors). It was clear that the suppressor T cells could show apparent antigen specificity, but all protein purification and cloning approaches failed to confirm that soluble suppressor factors could account for this [9]. In the meantime the nature of the antigen receptor on T-cells was discovered and characterized both at the gene and protein level. A precise link between the T-cell antigen receptor and the antigen-specific suppressor factors has yet to be unambiguously demonstrated [10–14]. This failure to identify the genetic source of antigen-specific suppressor factors led to a profound skepticism about this research topic [15]. This was further supported by the successful identification of cytokines such as TGF-b, interferons and IL-10 as suppressive cytokines that lacked antigen specificity [16–19].
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کلمات کلیدی:
Steroid-sensitive mechanism of soluble immune response suppressor ... https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by HW Schnaper - 1987 - Cited by 34 - Related articles Soluble immune response suppressor (SIRS), a lymphokine that suppresses antibody production and delayed type hypersensitivity in vivo, has been detected in ... Soluble immune response suppressor (SIRS) — Northwestern Scholars https://www.scholars.northwestern.edu/en/.../soluble-immune-response-suppressor-sirs... Soluble immune response suppressor (SIRS). / TM, Aune; HW, Schnaper; Schnaper, H William. Methods in Enzymology: Immunochemical Techniques. ed. Mode of Action of a Soluble Immune Response Suppressor (Sirs ... www.jimmunol.org/content/120/2/481.abstract by T Tadakuma - 1978 - Cited by 92 - Related articles Abstract. Soluble immune response suppressor (SIRS) is a product of concanavalin A activated Ly 2,3+ T cells which suppresses plaque-forming cell response ... Soluble Immune Response Suppressor (SIRS ... - ResearchGate https://www.researchgate.net/.../299567380_Soluble_Immune_Response_Suppressor_SI... A previously studied immunosuppressive cytokine, Soluble Immune Response Suppressor (SIRS), may have relevance to current studies of immune ... A regulatory system for soluble immune response suppressor ... www.kidney-international.org/article/S0085-2538(15)34942-5/pdf by HW Schnaper - 1990 - Cited by 29 - Related articles has been determined that subjects with steroid-responsive nephrotic syndrome (SRNS) produce the lymphokine, soluble immune response suppressor (SIRS). Soluble immune response suppressor | definition of soluble immune ... medical-dictionary.thefreedictionary.com/soluble+immune+response+suppressor Looking for online definition of soluble immune response suppressor in the Medical Dictionary? soluble immune response suppressor explanation free. What is ... Isolation Characterization, and Utilization of T Lymphocyte Clones https://books.google.com/books?isbn=032314537X C Fathman - 2012 - Medical Mechanism of action of macrophage-derived suppressor factor produced by soluble immune response suppressor treated macrophages. J. Immunol. 127 ...
