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عنوان فارسی مقاله:
تعیین ژنتیکی نمره ترابکولار استخوان (TBS) و تراکم مواد معدنی استخوان: تجزیه و تحلیل دو متغیره
عنوان انگلیسی مقاله:
Genetic determinant of trabecular bone score (TBS) and bone mineral density: A bivariate analysis
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Trabecular bone score (TBS), as the terminology implies, is an index of bone fragility. TBS was derived from the dual energy X-ray absorptiometry image to describe skeletal texture of microarchitecture [1]. Several studies have shown that lower values of TBS were associated with increased risk of fragility fracture [2], and more importantly, the association was independent of bone mineral density (BMD) and age [3]. The independent contribution of TBS to fracture risk prediction suggests that a measurement of TBS could improve the accuracy of fracture risk assessment for an individual [4,5]. Despite the emerging role of TBS in fracture risk assessment, the etiology of TBS has been less well documented. In population based studies, TBS is strongly related to lumbar spine BMD, with the coefficient of correlation ranging between 0.6 and 0.7 [6,7]. As with BMD, TBS is inversely related to advancing age and positively associated with greater body mass index [6]. Moreover, the distribution of TBS closely follows a normal (bell-shaped) distribution with an almost constant variance across populations. It is likely that the bell-shaped distribution of TBS is a result of effects arising from segregating alleles at multiple loci. Thus, it could be reasonably hypothesize that the between-individuals variation in TBS is partially determined by hereditary factors. The present study was designed to test the above hypothesis. Our primary aims were to determine the relative contributions of geneticand environmental factors to the between-individual variation in TBS. We also tested the hypothesis that the co-variation between TBS and BMD is partly determined by shared genetic factors.
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کلمات کلیدی:
Genetic determinant of trabecular bone score (TBS) and bone mineral ... iranarze.ir/wp-content/uploads/2016/10/E2366.pdf Genetic determinant of trabecular bone score (TBS) and bone mineral density: A bivariate analysis. Lan T. Ho-Pham a,⁎, Didier Hans c, Minh C. Doan b, Linh D. Genetic determinant of trabecular bone score (TBS ... - ResearchGate https://www.researchgate.net/.../306551524_Genetic_determinant_of_trabecular_bone_s... Nov 11, 2016 - Introduction: Trabecular bone score has emerged as an important predictor of fragility fracture, but factors underlying the individual differences ... Trabecular bone score (TBS): Method and applications - Bone www.journals.elsevierhealth.com/article/S8756-3282(17)30035-2/fulltext by P Martineau Trabecular bone score (TBS) is a texture index derived from standard lumbar ..... known to be determinants of fracture risk independent of BMD, which are not ... Assessment of Fat distribution and Bone quality with Trabecular Bone ... https://www.nature.com › Scientific Reports › Articles by S Lv - 2016 - Cited by 7 - Related articles Apr 26, 2016 - BMD, trabecular bone score (TBS), and body fat distribution were ... trunk, or limbs fat) showed significant inverse association with TBS (β = −0.611, ..... Depot-specific steroidogenic gene transcription in human adipose tissue . PRIME PubMed | Trabecular bone scores and lumbar spine bone ... https://wwww.unboundmedicine.com/.../Trabecular_bone_scores_and_lumbar_spine_bo... Trabecular bone scores and lumbar spine bone mineral density of US adults: ... data exist on demographic and body size relationships for trabecular bone score (TBS), ... Genetic determinant of trabecular bone score (TBS) and bone mineral ... Ho-Pham LT[au] - PubMed Result www.ajcn.org/external-ref?access_num=Ho-Pham%20LT&link_type... Delineating the Relationship Between Leptin, Fat Mass, and Bone Mineral Density: A ... Genetic determinant of trabecular bone score (TBS) and bone mineral ... The OsteoLaus Cohort Study - Schattauer https://www.schattauer.de/index.php?id=5236&mid=17798&L=1 Keywords. Trabecular Bone Score (TBS), bone mineral ... TBS-Wert (Trabecular Bone Score), Knochenmi- .... genetic determinants associated with. CVRFs. References in Composition and microarchitecture of human trabecular ... www.canadianjournalofdiabetes.com/article/S8756-3282(13)00062-8/references Composition and microarchitecture of human trabecular bone change with age and ..... Genetic determinant of trabecular bone score (TBS) and bone mineral ...
