دانلود رایگان مقاله لاتین تب خوکی از سایت الزویر
عنوان فارسی مقاله:
مهار آزمایشگاهی تب خوکی آفریقایی ویروس توپوایزومراز II با مختل کردن تکثیر ویروس
عنوان انگلیسی مقاله:
In vitro inhibition of African swine fever virus-topoisomerase II disrupts viral replication
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
African swine fever (ASF) is a highly contagious hemorrhagic disease that affects domestic and wild suids. Clinical signs may vary from a hyperacute form, with 100% mortality, to a less common chronic and asymptomatic forms that can turn pigs into carrier state (Costard et al., 2009; Penrith and Vosloo, 2009). Until today there is no effective vaccine or treatment for ASF and control strategies include, among others, quarantine and compulsory slaughter of affected animals (reviewed in Gallardo et al., 2015; Michaud et al., 2013). The economic losses from these measures can disrupt both the local and, in severe outbreaks, the national economy due to international trade restrictions (Costard et al., 2009; Michaud et al., 2013). Nowadays, ASF is endemic in most of the sub-Saharan countries and in the Italian island of Sardinia for more than 35 years (Costard et al., 2009; Mur et al., 2016). In 2007, it was introduced in Georgia spreading to Armenia, Azerbaijan, Russia, to Ukraine in 2012 and, to Belarus in 2013 (reviewed in S anchez-Vizcaíno et al., 2013, 2015). In 2014, ASF reached the European Union, namely Lithuania, Poland, Estonia and Latvia (reviewed in Sanchez-Vizcaíno et al., 2015 ). The etiological agent of the disease is the African swine fever virus (ASFV), a large (z200 nm) enveloped icosahedral double-stranded DNA virus (170e190 kbp). ASFV is the only known Asfarviridae member and infects different species of soft ticks (Ornithodoros spp), wild and domestic pigs (reviewed in Boinas et al., 2014; Tulman et al., 2009). * Corresponding author. Its genome encodes for 151e167 genes depending on the strain,however, about half of them lack any known or predictable function (Chapman et al., 2008; reviewed in Dixon et al., 2013). Remarkably, ASFV is the only known virus that infects mammals encoding for a protein with type II DNA topoisomerase activity (ASFV-Topo II) (Coelho et al., 2015), sharing high similarity with bacterial topoisomerases, although its sequence homology with eukaryotic type II topoisomerases is low (Baylis et al., 1992; García-Beato et al., 1992; Gadelle et al., 2003; Coelho et al., 2015). Type II topoisomerases control DNA topology during replication, transcription, chromosome condensation-decondensation and segregation by catalysing transient double-stranded breaks in one helix DNA, pass a second DNA helix, and then close the gate, in all forms of life (reviewed in Champoux, 2001; de Souza et al., 2010; Forterre et al., 2007).
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کلمات کلیدی:
Effect of rifamycin derivatives and coumermycin A1 onin vitro RNA ... link.springer.com/article/10.1007/BF01314866 by ML Salas - 1983 - Cited by 29 - Related articles ... and coumermycin A1 onin vitro RNA synthesis by African swine fever virus ... II DNA topoisomerases, inhibited strongly RNA synthesisin vitro by ASF virus ... DNA Topoisomearases: Biochemistry and Molecular Biology https://books.google.com/books?isbn=008058120X 1994 - Science In vitro and intracellular inhibition of topoisomerase II by antitumor agent merbarone. ... A gene homologous to topoisomerase II in African swine fever virus. [PDF]African swine fever virus thymidylate kinase gene: sequence and ... citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.519.6611&rep=rep1... by RJ Ydfiez - 1993 - Cited by 15 - Related articles African swine fever (ASF) virus, the causative agent of a severe and economically ... topoisomerase II (Garcia-Beato et al., 1992b), DNA ligase (Hammond et al., ... Fernando Ferreira - Google Scholar Citations scholar.google.com/citations?user=vAmusIMAAAAJ&hl=en Translate this page Professor, Department of Morphology and Function, Faculty of Veterinary Medicine, Lisbon - fmv.ulisboa.pt Conjugation of human topoisomerase 2α with small ubiquitin-like modifiers 2/3 in ... In vitro inhibition of African swine fever virus-topoisomerase II disrupts viral ... Origin and Evolution of Viruses - Page 471 - Google Books Result https://books.google.com/books?isbn=0080538231 Esteban Domingo, Robert G. Webster, John F. Holland - 1999 - Medical DNA is encoded by vaccinia virus (Shuman and Moss, 1987), while ASFV codifies for a type II topoisomerase whose possible role in DNA ... finding that the specific inhibitor of this enzyme, coumermycin A1, inhibits in-vitro transcription by ASF virions (Salas et al., 1983). ... AFRICAN SWINE FEVER VIRUS; A MISSING LINK? Fernando Ferreira | LinkedIn https://pt.linkedin.com/in/fernando-ferreira-8309898 Lisboa e Região, Portugal - Assistant Professor at Faculty of Veterinary Medicine - Faculty Veterinay Medicine African swine fever (ASF) is a viral swine disease against which neither an effective ... DNA topoisomerase inhibitors) fully abrogate ASFV replication in vitro.
