دانلود رایگان مقاله لاتین بیومیمتیک پلیمری از سایت الزویر
عنوان فارسی مقاله:
بیومیمتیک پلیمری مبتنی بر نانوکامپوزیت نقره به عنوان پلت فرم ضد میکروبی
عنوان انگلیسی مقاله:
Biomimetic polymer-based Ag nanocomposites as a antimicrobial platform
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Bacterial biofilms are the surface-associated communities of undesirable attached microorganisms encased in a hydrated extracellular polymeric substances (EPS) matrix [1,2]. They represent a widespread and expensive problem, because such accumulation of bacteria could occur everywhere in water-based equips in contact with different materials, and also because once the biofilm state is established, it is almost impossible to eliminate with an inher-ently external resistance. The formation of bacterial biofilms on indwelling medical devices is of particular concern, as these bacteria hold a significantly increased (10–1000 fold) resistance to antibiotics, [3,4] which makes them a major cause of morbidity and mortality in nosocomial infections (NI) worldwide [5,6]. In order to reduce the growing incidence of NI cases and associated hospitalization costs, there is an immediate need for the development of antimicrobial surfaces able to resist microorganism attachment and prevent bacterial infection. A variety of antimicrobial surfaces have been generated through impregnation of materials with active biocides or adsorption of antimicrobial agents onto substrate surfaces, allowing the slow release of the agents into the near surroundings or their direct targeting to the adhered cells [7,8]. However, the destabilizing effect, potential toxicity, and increased antibiotic resistance of antimicrobial agents limit their biomedical applications [6,9]. Recently, several studies have explored a mussel-inspired method involving polydopamine (PDA) as a biomimetic surface modifier on various organic and inorganic substrates, including metals, semiconductors, polymers, and ceramics. Owing to the multiple functional groups present in the PDA thin film formed on the substrate surface, the PDA-functionalized surfaces could be easily conjugated with organic components, promoting electroless metal depositions and nanomaterials coating [10–14]. In addition, PDAfunctionalized hybrid metal nanoparticles (NPs) such as Ag NPs, and have shown antibacterial potency. Sureshkumar et al. have reported that dopamine coating anchoring silver (Ag) NPs onto magnetic nanofibers grants antibacterial activity to the magnetic Ag nanocomposite [15]. Xu et al. fabricated a microfiltration membrane deposited with dopamine and then functionalized with Ag and Au nanoparticles, and demonstrated its antibacterial efficacy against gram-negative Escherichia coli and gram-positive Staphylococcus aureus [16]. Therefore, alternative antimicrobial strategies based on nanoparticles, typically Ag, have the potential to overcome the limitations of antimicrobial agents, including antibiotic resistance [1,17,18]. However, such synthetic processes often need harsh conditions and multi-step synthesis procedures, and may be harmful for cell survival [19,20]. Thus, facile and simple methods for preparing biocompatible and antimicrobial nanomaterials are being pursued. Inthis study, we introduce anapproachto create anantibacterial surface by simple immersion and coating of a biomimetic molecular dopamine onto glass substrates, a process which enhances the adsorption of Ag NPs. We evaluate the dopamine/Ag nanocomposite exhibits antimicrobial characteristics against model microbes E. coli and also possess anti-biofilm formation potential. Moreover, we demonstrate that the selective biocompatibility of the prepared dopamine/Ag nanocomposite towards endothelial cells. The present results offer a potential strategy for preventing the formation of bacterial biofilms on indwelling medical devices and for decreasing the incidence of nosocomial infections, exploiting the remarkable adhesion properties of dopamine for anchoring Ag on a variety of substrates.
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کلمات کلیدی:
Bioinspired and Biomimetic Polymer Systems for Drug and Gene ... onlinelibrary.wiley.com › ... › Biopharmaceuticals & Pharmaceutical Biotechnology Dec 19, 2014 - Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, ... Biomimetic Polymers - Macromolecular Chemistry Group www.mmc.chemie.uni-goettingen.de/biomimetic_polymers.htm This project aims at the translation of biological principles to synthetic polymers in order to arrive at materials with greatly enhanced mechanical properties. Purdue Chemistry: Wilker Laboratory: Biomimetic Polymers https://www.chem.purdue.edu/wilker/research/biomimetic-polymers.html Biomimetic polymers for new materials. Mussels by the river. New Materials Inspired by Nature. As we learn how sea creatures stick we can use this information ... Biomimetic Polymers - Springer link.springer.com/book/10.1007%2F978-1-4613-0657-3 Biomimetic Polymers ... Biomimetic Reactions Using Organized Polymeric Supports · G. Wulff ... Polymeric Biomimetic Catalysts Based on 4-Diallylaminopyridine. Biomimetic polymers: Tough and smart - Nature www.nature.com › Journal home › Archive › News and Views Biomimetic polymers: Tough and smart. Richard A. L. Jones. Richard A. L. Jones is at the Department of Physics and Astronomy, University of Sheffield, Hicks ... Biomimetic Polymers, Molecular Imprinting and Nanostructuration - UTC www.utc.fr/~wmpi/ Research Group Karsten Haupt. Molecular Imprinting Technology. movie. Polymer with theophylline-specific binding site ... Biomimetic polymer applications - ResearchGate https://www.researchgate.net/post/Biomimetic_polymer_applications May 10, 2017 - Hi, anyone here can share the trend or interesting applications of biomimetic polymer science/technologies? Cheers!
