دانلود رایگان مقاله لاتین بیماری کولیت اولسروز از سایت الزویر
عنوان فارسی مقاله:
بروز اینترلوکین 23p19 در بیماران مبتلا به کولیت اولسروز و ارتباط آن با شدت بیماری
عنوان انگلیسی مقاله:
Interleukin-23p19 expression in patients with ulcerative colitis and its relation to disease severity
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Inflammatory bowel disease consists of two distinct diseases: Crohn’s disease (CD) and ulcerative colitis (UC). Both diseases may arise because of the combination of genetic variations and alterations in bacterial flora that can subsequently drive a dysregulated immune response that results in chronic intestinal inflammation [1,2]. Interleukin (IL)-23 is a member of a small family of proinflammatory cytokines, consisting of a p19 subunit and a common p40 subunit that is shared with IL12 [3]. The receptor for IL-23 (IL-23R) consists of the IL-12R beta 1 subunit and a novel component termed “IL-23R” [4], which is expressed predominantly on T cells, natural killer (NK) cells, and natural killer T (NKT) cells, and to a smaller extent on monocytes, macrophages, and dendritic cells (DCs) [5]. Interleukin 23 has a crucial role in the pathogenesis of several immune-mediated inflammatory diseases by recruiting several inflammatory cells and Th17 cells [6,7]. Interleukin 23 promotes Th17 cells in producing tumor necrosis factor alpha (TNFa), IL-17, IL-6, IL-22, granulocyte-macrophage colony-stimulating factor, and other novel factors, which are associated with the induction of autoimmune inflammation [6,8,9]. This study was performed to determine whether the mucosal expression of IL-23p19 has a role in the pathogenesis of UC and to elucidate its relation to disease severity.
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کلمات کلیدی:
Expression of Interleukin-12-Related Cytokine Transcripts in ... - NCBI https://www.ncbi.nlm.nih.gov/labs/articles/15674109/ Nov 14, 2009 - Expression of Interleukin-12-Related Cytokine Transcripts in Inflammatory Bowel Disease: Elevated Interleukin-23p19 and Interleukin-27p28 in Crohn's Disease but Not in Ulcerative Colitis ... is a heterodimer whose p40 subunit is identical to IL-12p40 whereas its p19 subunit is distantly related to IL-12p35. Serum interleukin-23 levels in patients with ulcerative colitis. - NCBI https://www.ncbi.nlm.nih.gov/pubmed/21931205 by M Mohammadi - 2011 - Cited by 12 - Related articles Serum interleukin-23 levels in patients with ulcerative colitis. ... Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in inflamed ... Expression of interleukin-12-related cytokine transcripts in ... https://www.researchgate.net/.../8058021_Expression_of_interleukin-12-related_cytokin... IL-23p19, IL-27p28, and EBI3 transcripts are strongly up-regulated in CD. ... Interleukin-23p19 expression in patients with ulcerative colitis and its relation to ... Serum Interleukin-23 Levels in Patients with Ulcerative Colitis iji.sums.ac.ir/article_17024_b61060f9c1944cfbee87229cb2aa4a7c.pdf by M Mohammadi - 2011 - Cited by 12 - Related articles Background: Patients with ulcerative colitis are at increased risk of inflammation. Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in ... inconsistent evidence on its role in ulcerative colitis. ..... in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease. Pharma-Nutrition: An Overview - Page 84 - Google Books Result https://books.google.com/books?isbn=3319061518 Gert Folkerts, Johan Garssen - 2014 - Medical ... disease risk loci in ulcerative colitis further defines their molecular relationship. ... and interleukin-12 expression in the gut of patients with Crohn's disease. ... bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's ...
