دانلود رایگان مقاله لاتین بیماری مربوط به سن از سایت الزویر
عنوان فارسی مقاله:
نقش sirtuins در پیری و بیماریهای مربوط به سن
عنوان انگلیسی مقاله:
The role of sirtuins in aging and age-related diseases
سال انتشار : 2015
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بخشی از مقاله انگلیسی :
SIRT1 seems to be the most philogenetically similar to yeast 186 Sir2, in terms of both amino-acid sequence and the profile of 187 enzymatic activity. It is also the most frequently studied and best 188 characterized human sirtuin. SIRT1 regulates mainly cellular 189 metabolic pattern, while its own activity is regulated by 190 availability of nutrients, being induced during moderate undernu- 191 trition (e.g. due to CR) [48]. 192 SIRT1 stimulates mitochondrial biogenesis, as well as catabo- 193 lism of triglycerides and cholesterol in liver, skeletal muscles and 194 adipose tissue. In addition, it inhibits glycolysis while activating 195 gluconeogenesis and fatty acid oxidation in mosttissues [49]. SIRT1 196 regulates gluconeogenesis and glycolysis through PGC-1a tran- 197 scription factor, which also results in the increased number and 198 function of mitochondria, both in laboratory animals and in vitro 199 [50,37].
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کلمات کلیدی:
Sirtuins in Aging and Age-Related Disease: Cell www.cell.com/abstract/S0092-8674(06)00892-0 by VD Longo - 2006 - Cited by 523 - Related articles Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast longevity factor. Functioning as either deacetylases or ADP ribosylases, ... Functions of sirtuins in ageing and age-associated diseases : Nuclear ... www.nature.com/nrm/journal/v17/n5/box/nrm.2016.14_BX2.html Mar 9, 2016 - Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control metabolism and ageing. Sirtuins modify proteins, and, in the ... From Sirtuin Biology to Human Diseases: An Update www.jbc.org/content/287/51/42444.long by C Sebastián - 2012 - Cited by 117 - Related articles Dec 14, 2012 - In addition to regulating aging, sirtuins play key roles in the maintenance ... in the development of many age-related diseases, including cancer, ... The sirtuin family's role in aging and age-associated pathologies - JCI https://www.jci.org/articles/view/64094/version/1/pdf/render the onset of numerous diseases associated with aging, such as can- cer and diabetes, as ... the age-related biology of sirtuins was cultivated. Although recent. Sirtuins Function as the Modulators in Aging-related Diseases in ... www.cmj.org/article.asp?issn=0366-6999;year=2015;volume...;spage...;epage... by QL Wang - 2015 - Related articles Jun 8, 2015 - Table 1: Age-related diseases in elderly population ... the regulatory mechanism of Sirtuins on aging as well as in aging-related diseases such ... Aging and Age-Related Disorders - Page 140 - Google Books Result https://books.google.com/books?isbn=1607616025 Stephen Bondy, Kenneth Maiese - 2010 - Medical Therefore, the above findings together suggest that sirtuins targeted at ... Sirtuins. in. Age-Related. Diseases. Recent research in the field of aging has begun to ... Searches related to sirtuins in aging and age-related diseases sirtuins wiki sirtuins foods sirtuin activators
