دانلود رایگان مقاله لاتین بازدارنده هیستون داستیلاز بوتیرات سدیم از سایت الزویر
عنوان فارسی مقاله:
اثر بازدارنده هیستون داستیلاز بوتیرات سدیم به رفتار جستجوی هروئین در هسته آکومبنس در موش
عنوان انگلیسی مقاله:
Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Heroin addiction is a chronic, relapsing brain disease characterized by persistent and uncontrolled drug seeking behavior. After abstinence, simple exposure to heroin or heroin-associated cues can lead to potent cravings and ultimately a resumption of heroin-seeking behavior. There is converging evidence showing that chromatin remodeling and epigenetic changes occur during both development and maintenance of drug addiction (Renthal et al., 2009). Epigenetic modifications such as histone acetylation may play a key modulator for drug-induced gene expression and long-lasting aspects of addiction (Nestler, 2014). Epigenetic alterations can register and maintain durable structural chromatin adaptations (Bird, 2007). Specific changes of the histone acetylation in the key brain reward regions (e.g., accumbens nucleus, prefrontal cortex) seem to contribute to drug-induced behaviors and neuroplasticity (McQuown and Wood, 2010; Renthal et al., 2009; Simon-O′Brien et al., 2015). The histone cores are composed of 8 subunits, two each of the histones H2A, H2B, H3 and H4. Now over 100 acetylations of histone have been identified with most having an unclear function (Tan et al., 2011; Finegersh et al., 2015). While four unique histone modifications such as H3 acetylated at lysine 14 (H3K14) or at lysine 18 (H3K18), and H4 acetylated at lysine 5 (H4K5) or lysine 8 (H4K8) are of interest because these acetylations of histone may be belong to the class of socalled common modification module that is present on active and poised promoters (Martin et al., 2012). Histone acetylation is a highly dynamic process regulated by two families of enzymes: histone acetyl transferases (HATs) and histone deacetylases (HDACs), which promote gene activation and gene repression, respectively. Indeed, inhibitors of HDAC promote the synaptic plasticity and the long-term memory (Barrett and Wood, 2008), and also alter rewarding responses to psychostimulants(e.g., cocaine, amphetamine), ethanol and nicotine (Kumar et al., 2005; Alaux-Cantin et al., 2013; Sakharkar et al., 2014; You et al., 2014; Pandey et al., 2008; Legastelois et al., 2013; Castino
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کلمات کلیدی:
Scholarly articles for deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus … of sodium butyrate, an inhibitor of histone deacetylase, … - Sun - Cited by 45 The histone deacetylase inhibitor sodium butyrate … - Simon‐O'Brien - Cited by 17 … of CaMKIIα in the nucleus accumbens is critical for … - Wang - Cited by 104 Search Results Effects of histone deacetylase inhibitor sodium butyrate on heroin ... https://www.ncbi.nlm.nih.gov/pubmed/27742468 by WS Chen - 2016 Oct 11, 2016 - Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats. Chen WS(1), Xu WJ(1), ... Effects of histone deacetylase inhibitor sodium butyrate on heroin ... www.sciencedirect.com/science/article/pii/S0006899316306990 by WS Chen - 2016 - Related articles Dec 1, 2016 - Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats. Wei-Sheng Chen ... The histone deacetylase inhibitor sodium butyrate decreases ... onlinelibrary.wiley.com/doi/10.1111/adb.12161/abstract by E Simon‐O'Brien - 2015 - Cited by 17 - Related articles Jul 8, 2014 - Abstract. Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin ... Wen Hua ZHOU-Ningbo Institute of Microcirculation and ... - ScholarMate www.scholarmate.com/scmwebsns/in/view?des3PsnId... Translate this page ... Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats, Brain Research, Vol 1652, pp 151-157, ... 5. Effects of histone deacetylase inhibitor sodium butyrate on heroin ... en.nankai.findplus.cn/n_index_findplus_en.php?h=articles... - Translate this page Title: Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats. Authors: Chen, W.-S. Xu, W.-J. Neurobiology of Mental Illness - Page 695 - Google Books Result https://books.google.com/books?isbn=0199934959 Dennis S. Charney, Pamela Sklar, Joseph D. Buxbaum - 2013 - Medical The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and ... Control of within-binge cocaine-seeking by dopamine and glutamate in the ... in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. .... of protein kinase A signaling and relapse of heroin-seeking behavior.
