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عنوان فارسی مقاله:

مجموعه بزرگ تنفسی اجباری از اکتینوباکتریا


عنوان انگلیسی مقاله:

The obligate respiratory supercomplex from Actinobacteria


سال انتشار : 2016



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مقدمه انگلیسی مقاله:

1. Introduction

The phylum Actinobacteria [1] comprises medically and economically very important species, such as industrial producers of a variety of bioactive molecules and human pathogens. Examples include Streptomycetes, which are the most abundant source of natural antibiotics [2], and the soil bacterium Corynebacterium glutamicum, which is used for production of glutamate and lysine at megaton scale per year and which has superior potential for production of other chemicals such as organic acids, diamines, or biofuels and for proteins [3,4]. Closely related to C. glutamicum are the diphtheria and tuberculosis (TB) causing species C. diphtheriae and Mycobacterium tuberculosis [5,6]. In aerobic respiration, which is a predominant form of cellular energy conversion in Actinobacteria, exergonic electron transfer through respiratory chain complexes with dioxygen as terminal acceptor generates proton motive force (PMF) that drives ATP synthesis. Respiratory complexes can associate in supramolecular associations, the so called respiratory supercomplexes. They have been intensely studied in mitochondria [7], in which they may organize electron flux for an optimal use of available substrates [8]. Little is known about the actinobacterial counterpart. An actinobacterial respiratory supercomplex was first reported for C. glutamicum [9,10]. In this supercomplex, electron transfer from menaquinol to dioxygen is facilitated by a sequential reaction of cytochrome bcc complex1 (bcc complex) and cytochrome aa3 oxidase (aa3 oxidase) which both contribute to PMF generation [11,12]. Copurification of the complexes demonstrated their supramolecular association and quinol oxidase activity [13]. No additional cytochrome c (cyt c) is present for electron transfer between the two complexes in C. glutamicum, as staining of protein extracts from whole cells for covalently bound heme showed the presence of a single, membrane bound c-type cytochrome, the di-heme QcrC subunit of bcc complex [13]. QcrC mediates electron transfer between the two enzymes, both heme groups of the di-heme class I cytochrome c are essential for the transfer.



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کلمات کلیدی:

Actinobacteria - Encyclopedia of Life Sciences www.els.net/WileyCDA/ElsArticle/refId-a0020366.html by ME Trujillo - ‎Related articles Actinobacteria are Gram‐stain‐positive microorganisms with high guanine plus cytosine content in their genome (>50%) Actinobacteria: Definition & Characteristics - Video & Lesson ... study.com/academy/lesson/actinobacteria-definition-characteristics.html This lesson covers a group of bacteria known as Actinobacteria. Learn about the unique characteristics of these bacteria and how they use these... Taxonomy, Physiology, and Natural Products of Actinobacteria mmbr.asm.org/content/80/1/1.full by EA Barka - ‎2016 - ‎Cited by 74 - ‎Related articles Mar 1, 2016 - SUMMARY Actinobacteria are Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ... Actinobacteria (High G + C Gram-Positive Bacteria) - Boundless https://www.boundless.com › ... › Gram-Positive Bacteria and Actinobacteria Learn more about actinobacteria (high g + c gram-positive bacteria) in the Boundless open textbook. Actinobacteria are a group of Gram-positive bacteria with ... Class Actinobacteria www.bacterio.net/actinobacteria.html Class Actinobacteria. Warning: In the List of Prokaryotic names with Standing in Nomenclature, an arrow (→) only indicates the sequence of valid publication of ... Morphological Identification of Actinobacteria | InTechOpen https://www.intechopen.com/.../actinobacteria.../morphological-identification-of-actinob... by Q Li - ‎2016 Feb 11, 2016 - Morphological Identification of Actinobacteria | InTechOpen, Published on: 2016-02-11. Authors: Qinyuan Li, Xiu Chen, Yi Jiang, et. Searches related to Actinobacteria actinobacteria classification actinobacteria in the gut actinobacteria characteristics actinobacteria definition actinobacteria antibiotics actinobacteria treatment actinobacteria aerobic or anaerobic actinobacteria in humans