دانلود رایگان مقاله لاتین اندوتلیوم عروق کوچک مغزی از سایت الزویر
عنوان فارسی مقاله:
اثر سرین N-arachidonoyl-L در اندوتلیوم عروق کوچک مغزی انسان
عنوان انگلیسی مقاله:
Effect of N-arachidonoyl-L-serine on human cerebromicrovascular endothelium
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The cerebromicrovascular endothelium derived from human brain (HBEC) plays a major role in the function of the blood brain barrier and contributes to vascular tone and blood flow. These cells are known to possess functional machinery to respond to endogenous and exogenous vasoactive substances as well as other factors [1]. HBEC also express CB1 and CB2 receptors that respond to endocannabinoids (e.g., 2-AG, anandamide) which induce Ca2þ influx and cytoskeleton (i.e., actin and vimentin) reorganization alone as well as in the presence of ET-1, a known potent vasoconstrictor [2,3]. N-arachidonoyl-L-serine (ARA-S) is one of many endogenous lipids found in the brain. This agent is chemically related to the endocannabinoid N-arachidonoyl ethanolamide and was shown to have similar properties (i.e., vasoactive [4], pro-angiogenic [5], pro-neurogenic [6], and neuroprotective) and a similar physiologic role as those described for endocannabinoids [4]. However, the originally described ARA-S induced endothelial-dependent vasodilation observed in vivo in rat abdominal and mesenteric vessels was not abrogated by CB1, CB2 or TRPV1- antagonists [4]. Thus, ARA-S has been considered a ‘cannabinoid-like’ substance since, in contrast to the other cannabinoids, it binds weakly to the known classical receptors, namely CB1 and CB2 [4]. These studies also demonstrated that ARA-S stimulated phosphorylation of 44/42 MAPK kinase and Akt protein kinase. The mechanism by which ARA-S affects endothelial responses (i.e., angiogenesis, wound healing, inflammatory responses, etc.) is variable and involves different receptors. For example, some studies indicate that ARA-S effects are mediated by GPR55 receptors [5,7] while other reports suggest that ARA-S mediated effects do not involve GPR55 [8]. Additional studies to clarify the precise mechanisms of ARA-Sinduced responses will likely indicate differences dependent upon the model being studied. In view of the above observations, it was of interest to evaluate if the cannabinoid-like substance, ARA-S, affected HBEC responses by examining its effects on cytoskeleton (actins) and signal transduction pathways.
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کلمات کلیدی:
Endocannabinoid-like N-arachidonoyl serine is ... - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.00841.x/full by X Zhang - 2010 - Cited by 43 - Related articles May 3, 2010 - Based on these findings, the effect of ARA-S on endothelial functions was further studied. ... The bioactive lipid L-α-lysophosphatidylinositol (LPI) and related lipids ... N-arachidonoyl serine, a recently identified endocannabinoid-like lipid ... Primary human dermal microvascular endothelial cells (HMVEC; ... REVIEW Vascular targets for cannabinoids: animal and human studies pubmedcentralcanada.ca/pmcc/articles/PMC3954478/pdf/bph0171-1361.pdf by C Stanley - 2014 - Cited by 34 - Related articles Jun 14, 2013 - lysophosphatidylinositol; NADA, N-arachidonoyl dopamine; OEA, ... cals that bind to cannabinoid receptors) caused their effects through ...... cerebromicrovascular ..... 2006), and N-arachidonoyl-L-serine (ARA-S, Milman et al.,. Endocannabinoids and traumatic brain injury - NCBI - NIH https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by E Shohami - 2011 - Cited by 83 - Related articles Keywords: 2-arachidonoyl-glycerol, N-arachidonoyl-L-serine, ... with CB1 and CB2 receptors on the cerebromicrovascular endothelial cells, which represent the .... Our study on the effect of eCBs on Ca2+ influx in human brain endothelial cells ... [PDF]Endocannabinoids and traumatic brain injury - Iowans for Medical ... files.iowamedicalmarijuana.org/petition/2012/bjp-aug-2011-1402-1410.pdf 2011 - Cited by 83 - Related articles role of CB1 in mediating these effects was demonstrated using selective antagonists or CB1 knockout mice. CB2 were ... 2-AG, 2-arachidonoyl-glycerol; AraS, N-arachidonoyl-L-serine; CB1, ... the cerebromicrovascular endothelial cells, which represent ..... eCBs on Ca2+ influx in human brain endothelial cells (HBEC). Rania Abu Tarboush - Google Scholar Citations scholar.google.com/citations?user=gMjAzXYAAAAJ&hl=en Scientist, Henry Jackson Foundation - mail.mil Effects of N-acetyl-L-cysteine and hyaluronic acid on HBOC-201-induced ... Effect of N-arachidonoyl-l-serine on human cerebromicrovascular endothelium. Serine - Wikipedia https://en.wikipedia.org/wiki/Serine Serine encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that ... It can be synthesized in the human body under normal physiological ... Industrially, L-serine is produced by fermentation, with an estimated ... genotype/phenotype correlation and outcome of these diseases their impact on the ...
