دانلود رایگان مقاله لاتین التیام زخم مولکول سم مار از سایت الزویر
عنوان فارسی مقاله:
به روز رسانی مختصری در مکانیسم های مولکولی بالقوه اساسی ضد میکروبی و قدرت التیام زخم مولکولهای سم مار
عنوان انگلیسی مقاله:
A brief update on potential molecular mechanisms underlying antimicrobial and wound-healing potency of snake venom molecules
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Hospitals represent a rich environment for several life-threatening bacteria worldwide. For instance, Gram-negative bacterial infection (particularly involving Pseudomonas species) is a serious problem in patients hospitalized with cystic fibrosis and burns [1]. The fatality rate is almost 50%, and such infections are difficult to treat with the existing antibiotics [2]. Moreover, sepsis and septic shock are host-derived inflammatory conditions resulting from a systemic response to the bacterial infections [3]. Indeed, sepsis, pneumonia, and other conditions caused by hospital-acquired infections are responsible for at least 48,000 deaths worldwide and cost $8.1 billion to treat infected individuals every year [4]. A number of infections acquired in hospitals are caused by potentially fatal bacteria such as Staphylococcus aureus, which can survive for extended periods on medical devices such as intravenous lines and catheter tubes. Nearly 40% of all nosocomial infections involve the urinary tract and use of catheters [5]. Conversely, >70% of nursing home residents are hospitalized every year and exposed to methicillin-resistant S. aureus (MRSA) [6]. A previous study reports that 4.4% of all S. aureus strains are MRSA among children treated with flucloxacillin for noninfected atopiceczema. A 15–20% prevalence of fusidic acid resistance and MRSA in children (infancy to school age) has been reported for infected atopic eczema [7]. Previous reports related to decubital ulcers and inflammatory skin diseases with erosive lesions and venous leg ulcers mention the key role of MRSA [8]. In addition, severe infections may also complicate 0.25–4% of major cardiac surgical procedures, causing death and morbidity, leading to higher costs [9,10]. Generally, in diabetes mellitus and AIDS, a normally mild infection can rapidly become life-threatening [11]. In the case of diabetic foot ulcers caused by S. aureus, which produces the Panton–Valentine leukocidin and toxic shock syndrome toxin 1, persistent tissue damage and inflammatory response are observed. As a result, the inflammation may be the source of ongoing tissue damage [11,12]. Exotoxins are actively secreted proteins produced by virulent strains of S. aureus and Streptococcus pyogenes [13], which cause tissue damage or dysfunction via diverse mechanisms. It is estimated that half of all S. aureus strains develop resistance to antibiotics such as methicillin. The emergence of vancomycinresistant Enterococcus species may accelerate the spread of vancomycin resistance genes through plasmids to other species. The diagnosis and treatment perspectives include technological advances for diagnosis by blood cultures, tissue swabs with culture, needle aspiration, X-ray, ultrasound, and computed tomography (CT) scan or magnetic resonance imaging (MRI) screening, depending on the clinical manifestations. However, these techniques fail to detect microorganisms sometimes [10] and subsequently delay proper treatment.eczema. A 15–20% prevalence of fusidic acid resistance and MRSA in children (infancy to school age) has been reported for infected atopic eczema [7]. Previous reports related to decubital ulcers and inflammatory skin diseases with erosive lesions and venous leg ulcers mention the key role of MRSA [8]. In addition, severe infections may also complicate 0.25–4% of major cardiac surgical procedures, causing death and morbidity, leading to higher costs [9,10]. Generally, in diabetes mellitus and AIDS, a normally mild infection can rapidly become life-threatening [11]. In the case of diabetic foot ulcers caused by S. aureus, which produces the Panton–Valentine leukocidin and toxic shock syndrome toxin 1, persistent tissue damage and inflammatory response are observed. As a result, the inflammation may be the source of ongoing tissue damage [11,12]. Exotoxins are actively secreted proteins produced by virulent strains of S. aureus and Streptococcus pyogenes [13], which cause tissue damage or dysfunction via diverse mechanisms. It is estimated that half of all S. aureus strains develop resistance to antibiotics such as methicillin. The emergence of vancomycinresistant Enterococcus species may accelerate the spread of vancomycin resistance genes through plasmids to other species. The diagnosis and treatment perspectives include technological advances for diagnosis by blood cultures, tissue swabs with culture, needle aspiration, X-ray, ultrasound, and computed tomography (CT) scan or magnetic resonance imaging (MRI) screening, depending on the clinical manifestations. However, these techniques fail to detect microorganisms sometimes [10] and subsequently delay proper treatment.
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کلمات کلیدی:
Wound Healing Activity and Mechanisms of Action of an Antibacterial ... journals.plos.org/plosone/article?id=10.1371/journal.pone.0080199 by RP Samy - 2014 - Cited by 16 - Related articles Feb 14, 2014 - The CaTx-II protein highlights distinct snake proteins as a potential source of ... Proteins/peptides with potent antimicrobial activity have been found in a wide ... These molecules are very attractive because of their biochemical ... the antimicrobial and wound healing activity of a C. adamanteus venom protein ... Venoms—Advances in Research and Application: 2012 Edition: ... https://books.google.com/books?isbn=1481607790 2012 - Medical wound. healing. Research findings, 'Evaluation of antibacterial activity of proteins and ... In this study, phospholipase A(2) (PLA(2)) purified from crotalid snake venom was ... were found to reproduce the bactericidal activity of its parent molecule. ... peptides showed very high microbicidal potency against Gram-negative and ... Marine Drugs | Free Full-Text | Novel Conopeptides of Largely ... - MDPI www.mdpi.com/1660-3397/14/11/199/htm by EKM Lebbe - 2016 - Cited by 3 - Related articles Oct 27, 2016 - Here, we report five novel peptides isolated from the venom of Conus ... Keywords: Conus; conotoxin; electrophysiology; antimicrobial tests; peptide characterization ...... and wound-healing potency of snake venom molecules. A brief update on potential molecular mechanisms underlying ... isi-dl.com/item/93718 A brief update on potential molecular mechanisms underlying antimicrobial and wound-healing potency of snake venom molecules. sciencedirect.com ...
