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عنوان فارسی مقاله:
استنت اورترال زیست تجزیه پذیر مبتنی بر ژلاتین با خواص مکانیکی بهبود یافته
عنوان انگلیسی مقاله:
Gelatin-based biodegradable ureteral stents with enhanced mechanical properties
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The most frequent adverse effects reported by patients experiencing ureteral stenting are pain and difficulties in urinary tract [1]. These problems can significantly impact patient quality of life with loss days of working, urinary leakage and sexual diffi- culties [2]. In last years, new ureteral stent designs have been tested with novel polymers, coatings and the incorporation of active compounds in an attempt to significantly reduce the most common problems like bacterial infection and encrustation [2–4]. Lange et al. [1] in a recent review concluded that the stent of the future will be degradable, in a control manner, and possible to coat or elute active compounds. No biodegradable ureteral stent is currently available on the market, although in the past years there has been a crescent interest in this field [1]. Polymers like polylactic acid, polyglycolic acid, poly(lactic-co-glycolic acid) and alginate-based materials have been used to develop the biodegradable ureteral stents [5–9]. Lumiaho et al. reported an in vivo study in pig model using polylactic acid and poly(lactic-co-glycolic acid) based stents which have shown good properties like antireflux properties and favorable drainage but the biocompatibility and the degradation profile were proven to be insufficient for clinical use [5,10,11]. The same ureteral stents showed a different behavior in a canine model, presenting a good biocompatibility and degradation which occurred in 12 weeks [12]. Other studies using poly(lactic-co-glycolic acid)-based ureteral stents reported favorable radiopaque and drainage properties, but the biocompatibility was compromised, according to what is reported in the literature [5,13–15]. The degradation of the ureteral stents must be uniform and homogenous or dissolving based on directionality, preventing the formation of fragments during the degradation process that can block the ureter [1,6,16]. Uriprene stent (Poly-Med, USA), a radiopaque, glycolic–lactic acid based stent has been designed to degrade in the direction of the bladder coil to renal coil preventing ureteral obstruction secondary to degrading stent fragments [1]. The in vivo pig model studies of Uriprene reported a good stability and biocompatibility, with a predictable degradation during 2–4 weeks while maintaining drainage. In our previous study, we reported an ureteral stent produced with natural based polymers processed by critical point drying with carbon dioxide [16]. This study was however not the first in literature to report alginatepolymer-based temporary ureteral stents. Lingeman et al. [9,17] showed in phase I and phase II clinical trials that these ureteral stents were designed to be intact at least 48 h before degradation with facilitated urinary drainage, favorable tolerability and safety profiles. The problem of these alginate-based stents is the fact that it presented a nonhomogeneous dissolution profile and fragmentation resulting in the need for secondary procedures to remove fragments in some patients.
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کلمات کلیدی:
Braided thin-walled biodegradable ureteral stent: Preliminary ... https://www.researchgate.net/.../258067180_Braided_thin-walled_biodegradable_uretera... Gelatin-based biodegradable ureteral stents with enhanced mechanical properties. "Clearly, increasing the gelatin concentration, the modification of the ... Evaluation of the Use of a Biodegradable Ureteral Stent After ... https://www.researchgate.net/.../11411688_Evaluation_of_the_Use_of_a_Biodegradable... Gelatin-based biodegradable ureteral stents with enhanced mechanical properties. The same ureteral stents showed a different behavior in a canine model, ... [PDF]10:38 a.m. 280. HydrUStent – Biodegradable Ureteral Stent, A. Barros 2017.biomaterials.org/sites/default/files/abstracts/0280.pdf HydrUStent – Biodegradable Ureteral Stent. Alexandre A. ... Statement of Purpose: Patients who have an ureteral stent .... (4) Barros A.A. et al, “Gelatin-based. Polymers as Ureteral Stents | Abstract - Mary Ann Liebert, Inc. publishers online.liebertpub.com/doi/abs/10.1089/end.2009.0516 by N Venkatesan - 2010 - Cited by 53 - Related articles Jan 14, 2010 - The majority of patients with indwelling ureteral stents are at an increased risk of ... Gelatin-based biodegradable ureteral stents with enhanced ... New Bioabsorbable Polylactide Ureteral Stent in the Treatment of ... online.liebertpub.com/doi/abs/10.1089/end.1999.13.107 by J LUMIAHO - 1999 - Cited by 41 - Related articles To evaluate the suitability of a new biodegradable double-helical spiral ... Gelatin-based biodegradable ureteral stents with enhanced mechanical properties. New Bioabsorbable Polylactide Ureteral Stent in the Treatment of ... online.liebertpub.com/doi/abs/10.1089/end.1999.13.107?src=recsys These preliminary results suggest that a biodegradable SR-PLA 96 stent ... Gelatin-based biodegradable ureteral stents with enhanced mechanical properties. Phase I Trial of a Temporary Ureteral Drainage Stent | Abstract online.liebertpub.com/doi/abs/10.1089/089277903321618734 by JE Lingeman - 2003 - Cited by 29 - Related articles Gelatin-based biodegradable ureteral stents with enhanced mechanical ... Braided thin-walled biodegradable ureteral stent: Preliminary evaluation in a canine ... References in In Vitro and Ex Vivo Permeability Studies of Paclitaxel ... www.jpharmsci.org/article/S0022-3549(17)30132-6/references 16Barros, A.A., Oliveira, C., Lima, E., Duarte, A.R.C., Reis, R.L. Gelatin-based biodegradable ureteral stents with enhanced mechanical properties. Appl Mater ...
