دانلود رایگان مقاله لاتین اختلال رشد اسکلتی پپتید ناتریورتیک از سایت الزویر
عنوان فارسی مقاله:
بازیابی اختلال رشد اسکلتی پپتید ناتریورتیک نوع C در مدل موشی تأخیر رشد القا شده از گلوکوکورتیکوئید
عنوان انگلیسی مقاله:
C-type natriuretic peptide restores impaired skeletal growth in a murine model of glucocorticoid-induced growth retardation
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Glucocorticoid (GC)-based drugs are widely used to treat various diseases because of their immunosuppressive and anti-inflammatory effects. However, the long-term use of these drugs causes many side effects on various tissues, including bone. The most notable deleterious effects on bone associated with GCs are osteoporosis and subsequent bone fractures [1]. These side effects on bone have been proposed to be caused by manifold functions of GCs, such as suppression of the proliferation and differentiation of osteoblasts, acceleration of the apoptosis of osteoblasts and osteocytes [2], and attenuation of the function of insulin-like growth factor-1 (IGF-1), which promotes bone formation [3, 4]. Moreover, it is well-known that long-term administration of GCs to children induces growth retardation. GC-induced growth impairment correlates with the dose of GCs [5]. Although it has been reported that GCs used for physiological replacement (0.075–0.125 mg/kg/day prednisone or 0.3–0.375 mg/kg/day hydrocortisone) can induce growth retardation [6], a recent study suggests that growth impairment is actualized when the GC dose exceeds 0.2 mg/kg/day prednisone equivalents [5]. Alternate-day treatment of boys with prednisone also involves growth impairment, and the impairment persists even after the treatment is discontinued, resulting in reduction of their adult height [7]. There are many studies concerning growth retardation due to GCs. Long-term, high-dose regimen of GCs induces apoptosis, impairs differentiation, prevents proliferation of growth plate chondrocytes, and inhibits bone growth [8,9]. GCs have direct effects on chondrocytes in growth plate and in addition, GCs impair the anabolic effects of growth hormone (GH)/IGF-1 axis on growth plate chondrocytes [10,11]. As for treatment of GC-induced growth retardation, GH therapy has been attempted but the effect was reported to be limited [12]. Ablation of Bax, the pro-apoptotic protein, was indicated to rescue GC-induced growth retardation [13], but effective therapy for GC-induced growth retardation has not been established.
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کلمات کلیدی:
C-type natriuretic peptide restores impaired skeletal growth in a ... https://www.researchgate.net/.../307883737_C-type_natriuretic_peptide_restores_impair... Nov 11, 2016 - C-type natriuretic peptide restores impaired skeletal growth in a murine model of glucocorticoid-induced growth retardation on ResearchGate, ... C-type natriuretic peptide restores impaired skeletal growth in a ... https://www.tripdatabase.com/.../9176702-C-type-natriuretic-peptide-restores-impaire... C-type natriuretic peptide restores impaired skeletal growth in a murine model of glucocorticoid-induced growth retardation. Bone, 2016. View rest of article at ... Stromal cell-derived factor 1/CXCR4 signaling is ... - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/art.24330/pdf by T Kitaori - 2009 - Cited by 384 - Related articles Site During Skeletal Repair in a Mouse Model. Toshiyuki Kitaori,1 Hiromu Ito,1 ... CXCL12/pre–B cell growth-stimulating factor) is a dom- ... steroid-induced osteoporosis (2). Although ...... graft restored impaired bone formation in SDF-1 / mice. RECENT RESEARCH ON THE GROWTH PLATE: Impact of ... jme.endocrinology-journals.org/content/53/1/T35.full by B Sederquist - 2014 - Cited by 23 - Related articles Aug 1, 2014 - The process of longitudinal bone growth is complex and tightly regulated by several factors. ... model of most bones is gradually replaced by calcified bone (Mackie et al. ... Growth is often impaired in children with chronic inflammatory ... to growth failure such as malnutrition, glucocorticoid (GC) therapy, and ...
