دانلود رایگان مقاله لاتین آنفولانزای a از سایت الزویر
عنوان فارسی مقاله:
JNJ872 مهار تکثیر ویروس آنفولانزای A بدون تغییر واکنش های ضد ویروسی سلولی
عنوان انگلیسی مقاله:
JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Influenza A viruses (IAVs) mutate rapidly. Rapid evolution allows emerging viruses to overcome the prevailing immunity in the human population and to cause global epidemics and pandemics (Belanov et al., 2015). In order to combat influenza outbreaks several antiviral drugs have been developed (Edinger et al., 2014; Loregian et al., 2014). In particular, amantadine, rimantadine, oseltamivir, zanamivir, laninamivir, peramivir and favipiravir (T- 705) were approved in USA for treatment of IAV infections. However, almost all IAV strains became resistant to amantadine and rimantadine, due to mutations in viral M2 protein (http://www. influenzareport.com/ir/drugs/amanta.htm). Oseltamivir is widely used for treating seasonal IAV infections; however, oseltamivirresistant IAV strains emerge and reduce the efficacy of the treatment due to mutations in viral NA protein (Li et al., 2015). Therefore, there is an unmet medical need for newer antivirals to treat influenza. JNJ872 is an investigational drug, which was designed to target viral PB2. Virus-directed JNJ872 has progressed to phase II clinical trials as an anti-influenza drug candidate (www.clinicaltrials.gov, NCT02342249 and NCT02532283) (Byrn et al., 2015; Clark et al., 2014). Here, we show that JNJ872 not only efficiently inhibited IAV infection of human macrophages, but also allowed the development of innate immune responses, and thus might have minimal side effects in vivo.
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کلمات کلیدی:
University of Helsinki - JNJ872 inhibits influenza A virus replication ... https://plu.mx/helsinki/a/0rP3SobRkUfTgIpXbjWAKaa8igoQfmUZZQ3dUlLg9aE/ JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Citation data: Antiviral research, ISSN: 1872-9096, Vol: 133, Page: 23- ... Multi-Omics Studies towards Novel Modulators of Influenza A Virus ... www.mdpi.com/1999-4915/8/10/269/htm by S Söderholm - 2016 - Cited by 3 - Related articles Sep 29, 2016 - Human influenza A viruses (IAVs) cause global pandemics and epidemics. ... D.E. JNJ872 inhibits influenza a virus replication without altering ... Full-Text PDF - MDPI.com www.mdpi.com/1999-4915/8/10/269/pdf by S Söderholm - 2016 - Cited by 3 - Related articles Sep 29, 2016 - Abstract: Human influenza A viruses (IAVs) cause global pandemics and ..... D.E. JNJ872 inhibits influenza a virus replication without altering ... Pimodivir | VX-787 | JNJ-872 | JNJ-63623872 | VRT-0928787 | CAS ... www.medkoo.com/products/7757 Pimodivir (VX-787, JNJ-872, VRT-0928787) purity > 98%, is in stock. .... JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res - : The AMEDEO Literature Guide www.amedeo.com/medicine/flu/antivres.htm Protective efficacy of Fc targeting conserved influenza virus M2e antigen ... JNJ872 inhibits influenza A virus replication without altering cellular antiviral ... Medical Systems Virology | FIMM https://www.fimm.fi/en/research/groups/kainov May 6, 2017 - Our group develops novel modalities against influenza A virus infections. ... JNJ872 inhibits influenza A virus replication without altering cellular ... Searches related to JNJ872 inhibits influenza A virus replication without altering pimodivir jnj-63623872
