دانلود رایگان مقاله لاتین آنالیز محاسبات ژنومی کلان داده از سایت الزویر
عنوان فارسی مقاله:
چالش ها و وضعیت فعلی در تجزیه و تحلیل محاسبات ژنومی کلان داده
عنوان انگلیسی مقاله:
The Current Status and Challenges in Computational Analysis of Genomic Big Data
سال انتشار : 2015
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مقدمه انگلیسی مقاله:
1. Introduction
Why do some siblings look alike but have different heights and/or blood types? How do people get old and suffer from diseases? It’s so amazing that nature always gets its rules to “design” living organisms. The rules are so stringent that humans are similar to each other, but they are also flexible enough to allow differences between any two individuals. In biological sciences, an observable trait or characteristic, such as hair color or body height, is called a phenotype. Phenotypes are the results of both genetics and environment, as well as their interactions. Even though we still know very little about how environments affect phenotypes, scientists have a relatively much better understanding in the genetic factors. In 1952, Alfred Hershey and Martha Chase found that DNA is the hereditary material in any organism [1]. DNA, deoxyribonucleic acid, is a double-helix macromolecule. Its two strands are composed of numerous lineararranged nucleotides. There are four kinds of nucleotides in total, which are distinguished by their nitrogen-containing nucleobases, guanine (G), adenine (A), thymine (T), and cytosine (C). In a DNA molecule, there are fragments called genes that can be coded for proteins, the basic functional elements in an organism. Such pro-tein coding genes only occupy less than 2% of all DNA sequences, but other nearly 98% of the sequences, though not directly coded for proteins, are not junk. Recent studies found that they contain various gene regulatory elements like enhancers and silencers, or code for noncoding RNAs, such as microRNAs, small nuclear RNA and long noncoding RNAs (lncRNA) [2–4]. In Eukaryotes, which have a nucleus in each of their cells, DNAs coil around proteins called histone and are densely organized into chromosomes, and stably exist in the nucleus (see Fig. 1). Another important biological macromolecule is called ribonucleic acid (RNA), which is the product of DNA transcription. RNAs are transcribed in the nucleus, and most of them are exported to the cytoplasm. They are single-stranded chains of nucleotides, distinguished by guanine (G), adenine (A), cytosine (C) and uracil (U). There are several kinds of RNA, such as messenger RNA (mRNA), transfer RNA (tRNA) and ribosomal RNA (rRNA). Messenger RNA is the most imperative modality of RNA. It can be further translated into proteins with the help of tRNA. Some other forms of RNAs include microRNAs and lncRNAs. Although most of them cannot be translated into functional proteins, they still play their roles in the regulation of gene expression
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کلمات کلیدی:
Computational analysis of miRNA targets in plants: current status and ... https://www.ncbi.nlm.nih.gov/pubmed/20858738 by X Dai - 2011 - Cited by 85 - Related articles Sep 21, 2010 - Computational analysis of miRNA targets in plants: current status and challenges. Dai X(1), Zhuang Z, Zhao PX. Author information: (1)Plant ... The current status and challenges in computational analysis of ... hub.hku.hk/handle/10722/210595 by Y Qin - 2015 - Cited by 13 - Related articles Jun 19, 2015 - Abstract, DNA, RNA and protein are three major kinds of biological macromolecules with up to billions of basic elements in such biological ... [PDF]Computational pan-genomics: status, promises and challenges pages.di.unipi.it/pisanti/PAPERS/BB-2016.pdf Oct 21, 2016 - genome as any collection of genomic sequences to be analyzed jointly or to be ... mains translate into common computational problems, point out relevant .... 'classical' pan-genomes consisting of sets of genes present in a. The Current Status and Challenges in Computational Analysis of ... - خانه zoodyab.ir/.../77914-the-current-status-and-challenges-in-computat... Translate this page Consequently, large genomic datasets are being generated and computational tools to analyzing these data are in urgent demand. This paper reviews several ... Computational pan-genomics: status, promises and challenges bib.oxfordjournals.org/content/early/2016/10/19/bib.bbw089.full 2016 - Cited by 10 - Related articles Oct 19, 2016 - Computational pan-genomics: status, promises and challenges ... containing genes present in all strains, and a 'dispensable' genome (also known as ... its (computational) analysis is frequently still done in an ad hoc manner. MicroRNAs in Plant Development and Stress Responses https://books.google.com/books?isbn=364227384X Ramanjulu Sunkar - 2012 - Science Nucleic Acids Res 39:155–159 Dai X, Zhuang Z, Zhao PX (2011) Computational analysis of miRNA targets in plants: current status and challenges. Integrated Uncertainty in Knowledge Modelling and Decision Making: ... https://books.google.com/books?isbn=3642395155 Zengchang Qin, Van-Nam Huynh - 2013 - Computers Dai, X., Zhuang, Z., Zhao, P.X.: Computational Analysis of miRNA Targets in Plants: Current Status and Challenges. Briefings in Bioinformatics, 1–7 (2010) 7.
