دانلود رایگان مقاله لاتین آلوفین امید تنوفوویر از سایت الزویر
عنوان فارسی مقاله:
آلوفین امید تنوفوویر (TAF) به عنوان جانشین فومارات تنوفوویر دیسوپروکسیل (TDF)
عنوان انگلیسی مقاله:
Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF)
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Tenofovir (Fig. 1) was first described in 1993 under the name of (R)-PMPA [(R)-9-(2-phosphonylmethoxypropyl)adenine], as an anti-HIV agent, together with its 2,6-diaminopurine derivative (R)-PMPDAP [1]. That (R)-PMPA was far more effective than azidothymidine (AZT) as an antiretroviral agent was ascertained in 1995 by Tsai et al., who demonstrated that (R)-PMPA when infected shortly (within a few days) before or after SIV (simian immunodeficiency virus) infection in rhesus macacus monkeys completely suppressed the infection [2], an observation that later on would prove the basis for the pre-exposure prophylaxis (PrEP) of HIV infections. To ensure the oral bioavailability of (R)-PMPA, its bis(isopropy loxycarbonyloxymethyl) ester was conceived [3,4], and this diester of tenofovir would then be formulated with fumarate, as TDF (tenofovir disoproxil fumarate) (Fig. 1). It would be marketed at Viread in 2001 for the treatment of HIV infections, and in 2008 for the treatment of hepatitis B virus (HBV) infections. In combination with emtricitabine (Emtriva, ()FTC) (Fig. 1), TDF was approved by the US FDA in 2004 for the treatment of HIV infections, and in 2012 for the prophylaxis of HIV infections. The combination of TDF with ()FTC has been marketed as Truvada. This single-tablet regimen (STR) was further extended in 2006 to efavirenz (Sustiva) (Fig. 1) in an STR, now called Atripla; in 2011 to rilpivirine (Edurant) (Fig. 1), in an STR, now called Complera (US)/Eviplera (EU), and in 2012 to elvitegravir (Fig. 1) and cobicistat (Fig. 1), resulting in a quadruple drug regimen, now termed Stribild. The route of tenofovir to Complera/Eviplera and Stribild has been described in previous review articles [5,6]. Here, I describe the advent of TAF (tenofovir alafenamide) and its potential for the treatment and prevention of HIV infections. Ray et al. [7] stated in their conclusion that TAF would be a promising new therapeutic agent for the lifelong treatment of HIV (infections).
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کلمات کلیدی:
U.S. Food and Drug Administration Approves Gilead's Vemlidy ... www.gilead.com/.../us-food-and-drug-administration-approves-gileads-vemlidy-tenof... Nov 10, 2016 - ... Gilead's Vemlidy® (Tenofovir Alafenamide) for the Treatment of Chronic ... FDA ) has approved Vemlidy® (tenofovir alafenamide, TAF) 25mg, ... Gilead's Investigational Tenofovir Alafenamide (TAF)-Based Single ... www.gilead.com/.../gileads-investigational-tenofovir-alafenamide-tafbased-single-tabl... Sep 24, 2014 - Gilead's Investigational Tenofovir Alafenamide (TAF)-Based Single Tablet HIV Regimen Meets 48-Week Primary Objective in Two Phase 3 ... Tenofovir Alafenamide, TAF - Gilead Sciences, Inc. www.gilead.com/.../european-commission-grants-marketing-authorization-for-gileads... Jan 11, 2017 - European Commission Grants Marketing Authorization for Gilead's Vemlidy® (Tenofovir Alafenamide, TAF) for the Treatment of Chronic ... TAF vs. TDF (original tenofovir)—improvements in safety | CATIE ... www.catie.ca/en/treatmentupdate/.../taf-vs-tdf-original-tenofovir-improvements-safet As mentioned previously in this issue of TreatmentUpdate, TAF is being tested ... TAF (tenofovir alafenamide) 10 mg + elvitegravir 150 mg + cobicistat 150 mg + ... TAF is coming | CATIE - Canada's source for HIV and hepatitis C ... www.catie.ca/en/treatmentupdate/treatmentupdate-211/anti-hiv-agents/taf-coming A new oral formulation of tenofovir has been developed by Gilead Sciences. The new formulation is called TAF (tenofovir alafenamide). In lab experiments with ... Tenofovir Alafenamide vs. Tenofovir Disoproxil Fumarate - Medscape www.medscape.com/viewarticle/831661 Objectives: To evaluate the safety and efficacy of the novel tenofovir prodrug, tenofovir alafenamide (TAF), as part of a single-tablet regimen (STR) for the initial ... Searches related to Tenofovir alafenamide (TAF) tenofovir alafenamide vs tenofovir disoproxil fumarate tenofovir alafenamide hbv tenofovir alafenamide approval tenofovir alafenamide emtricitabine tenofovir alafenamide hemifumarate tenofovir alafenamide brand name tenofovir alafenamide side effects tenofovir alafenamide price
