دانلود رایگان مقاله لاتین آسپرین از سایت الزویر
عنوان فارسی مقاله:
یک ارزیابی مجدد انتقادی از آسپرین برای پیشگیری ثانویه در بیماران مبتلا به بیماری های ایسکمیک قلب
عنوان انگلیسی مقاله:
A critical reappraisal of aspirin for secondary prevention in patients with ischemic heart disease
سال انتشار : 2016
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بخشی از مقاله انگلیسی :
Accepting that aspirin was a proven therapy for secondary prevention and acknowledging its relatively weak antiplatelet effect—the advent of adenosine diphosphate (ADP)—receptor blocking agents led to the investigation of the capacity to improve patient's outcomes through increased platelet inhibition with more potent agents or with the addition of a second antiplatelet agent on top of baseline aspirin. The Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events (CAPRIE) trial enrolled 19,195 stable patients with prior stroke (n = 12,083), MI (n = 11,630), or peripheral arterial disease (n = 11,592) to ASA 325 mg or clopidogrel 75 mg daily for approximately 2 years.13 The aspirin arm had a 5.83%/y event rate for the combined end point of vascular death, MI, or ischemic stroke. Clopidogrel monotherapy was associated with a modest reduction in the combined end point (5.32%/y) with a relative risk reduction of 8.7% (95% CI 0.3-16.5, P = .043) with no major differences in terms of safety. Aspirin in fact had numerically increased rates of severe bleeding (1.55% vs 1.38%, not significant), severe intracranial hemorrhage (0.43% vs 0.31%, not significant), and gastrointestinal hemorrhage (any 2.66% vs 1.99% [P b .05] and severe 0.71% vs 0.49% [P b .05]) over a mean duration of follow-up of 1.9 years.13,14 In patients with an acute stroke or transient ischemic attack (n = 13,199), ticagrelor monotherapy (180-mg loading dose followed by 90 mg twice daily) has recently been compared with aspirin monotherapy (300-mg loading dose followed by 100 mg daily) for 90 days.15 Ticagrelor was associated with a nonsignificant reduction in the combined end point of 90 day stroke, MI, or death (ticagrelor 6.7% vs clopidogrel 7.5%; hazard ratio [HR[ 0.87, 95% CI 0.76-1.01). Major bleeding occurred in 0.5% of ticagrelor-treated patients and in 0.6% of aspirin-treated patients with intracranial hemorrhage in 0.2% and 0.3% and fatal bleeding in 0.1% and 0.1%. Although this study was not in patients with established coronary artery disease, it demonstrates a similar safety profile of ticagrelor monotherapy to aspirin monotherapy despite ticagrelor's enhanced potency.
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کلمات کلیدی:
aspirin-tablet : Uses, Side Effects, Interactions, Pictures, Warnings ... www.webmd.com/drugs/2/drug-1082-3/aspirin-oral/aspirin---oral/details Find patient medical information for aspirin-tablet on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Aspirin Quiz: The Wonder Drug in Your Medicine Cabinet - WebMD www.webmd.com/heart/rm-quiz-aspirin Sure, you take two aspirin for a headache, but it can do so much more. From your health to your household, find out fun facts about this little pill. All About Aspirin™ - Bayer https://www.bayer.com/en/aspirin.aspx Oct 27, 2016 - With its more than 115 years of age, Aspirin™ can look back at a rich, long-standing history and exciting future. Thanks to its active ingredient ... Safe Daily Use of Aspirin > Aspirin for Reducing Your Risk of Heart ... https://www.fda.gov/drugs/resourcesforyou/.../safedailyuseofaspirin/ucm291433.htm May 2, 2014 - You can walk into any pharmacy, grocery or convenience store and buy aspirin without a prescription. The Drug Facts label on medication ... Aspirin: Side Effects, Dosage, Uses - Healthline www.healthline.com/drugs/aspirin/oral-tablet Aug 19, 2014 - ASPIRIN (AS pir in) is a pain reliever. It is used to treat mild pain and fever. This medicine is also used as directed by a doctor to prevent and to ... Aspirin: MedlinePlus Drug Information https://medlineplus.gov › Drugs, Herbs and Supplements Jun 15, 2016 - Aspirin: learn about side effects, dosage, special precautions, and more on MedlinePlus. Searches related to aspirin aspirin structure aspirin classification aspirin brands aspirin in pregnancy aspirin nsaid aspirin dosage aspirin antiplatelet aspirin vs ibuprofen
