دانلود رایگان مقاله لاتین آستروسیت التهابی از سایت الزویر
عنوان فارسی مقاله:
نوآوری درمانی: آستروسیتهای التهابی واکنشی به عنوان اهداف التهاب
عنوان انگلیسی مقاله:
Therapeutic innovation: Inflammatory-reactive astrocytes as targets of inflammation
سال انتشار : 2017
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مقدمه انگلیسی مقاله:
1. Introduction
Inflammatory cells are important contributors to the pathophysiological response to injury. Penetration through the bloodebrain barrier (BBB) is achieved by circulating bone-marrow-derived leukocytes or monocytes, which can transform into macrophages/ microglia. These cells secrete cytokines that promote tissue damage (Medzhitov, 2008; Waisman et al., 2015). The BBB consists of capillary endothelial cells containing specialized tight junctions and surrounded by a basement membrane, which is composed of extracellular matrix components, pericytes and astrocytic perivascular endfeet (Abbott et al., 2006). The gram-negative bacterial endotoxin lipopolysaccharide (LPS) induces the conversion of endothelial cells into activated fibroblasts that show a myofibroblast-like protein profile. This process is mediated by the Toll-like receptor 4 (TLR4)/NF-kB pathway (Sarmiento et al., 2014). Astrocytes are now known to exert either potent proinflammatory functions or crucial protective anti-inflammatory functions that are regulated by specific signaling inputs (Hansson, 2010; Zeng et al., 2013; Hansson and Skioldebrand, 2015 € ). Their processes establish contacts with the BBB and the processes of other astrocytes via gap junctions, thereby forming networks of coupled astrocytes (Cornell-Bell et al., 1990; Blomstrand et al., 1999; Guthrie et al., 1999; Nedergaard et al., 2003). At sites of CNS tissue damage, astrocytes become reactive and form scar borders, which serve as functional barriers and have the potential to release diverse molecules that affect nearby cells. Astrocyte dysfunction can be caused by genetic polymorphisms or by exposure to molecular signals derived from infections or trauma, which can alter astrocyte inflammatory regulation and lead to detrimental effects (Sofroniew, 2015), including the alteration of astrocyte signaling mechanisms (Hansson, 2010, 2015).
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کلمات کلیدی:
Astrocytes: biology and pathology - NCBI - NIH https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by MV Sofroniew - 2010 - Cited by 1884 - Related articles Dec 10, 2009 - Keywords: Astrocyte, Reactive astrogliosis, Glial scar, GFAP, Pathology, ..... and reactive astrocytes can exert both pro- and anti-inflammatory effects on microglia [67, 148]. ... In a manner analogous to inflammation, reactive astrogliosis also has .... Astrocytes can be both targets of, as well as responders to, ... Astrocyte barriers to neurotoxic inflammation - NCBI - NIH https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253239/ by MV Sofroniew - 2015 - Cited by 126 - Related articles Reactive astrocytes have the potential to release diverse molecules that impact in many ..... reducing astrocyte pro-inflammatory effects may be useful targets. Reactive astrocytes as therapeutic targets for CNS disorders https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by ME Hamby - 2010 - Cited by 188 - Related articles In addition, astrocytes respond to all forms of CNS insults such as infection, ... When considering the potential for reactive astrocytes as therapeutic targets, it is ... as over production of reactive oxygen species (ROS) or certain inflammatory ... Therapeutic innovation: Inflammatory-reactive astrocytes as targets of ... isi-dl.com/item/302668 ... wiley.com, worldscientific.com. SEARCH. Therapeutic innovation: Inflammatory-reactive astrocytes as targets of inflammation. sciencedirect.com. Source Link ... Coupled cell networks are target cells of inflammation, which can ... https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-015-0091-2 by E Hansson - 2015 - Cited by 7 - Related articles Jul 25, 2015 - These blood cells are transformed into reactive microglia, which produce pro-inflammatory cytokines and activate astrocytes. This combined ... The role of inflammation in depression: from evolutionary imperative to ... www.nature.com/nri/journal/v16/n1/full/nri.2015.5.html Dec 29, 2015 - Transmitting stress-induced inflammatory signals to the brain. ... Cytokine targets in the brain: neurotransmitters and neurocircuits. ..... stimulation of astrocyte Glu release, in part by induction of reactive oxygen species (ROS) ... Astrogliosis - Wikipedia https://en.wikipedia.org/wiki/Astrogliosis Astrogliosis is an abnormal increase in the number of astrocytes due to the destruction of ... Astrocytes are involved in the complex regulation of CNS inflammation that is likely to be context-dependent and ... Pertaining to anti-inflammatory effects, reactive scar-forming astrocytes help reduce the spread of inflammatory cells ... Searches related to Inflammatory-reactive astrocytes as targets of inflammation astrocytes function astrocytes blood brain barrier astrocyte definition astrocyte cells function microglia oligodendrocytes ependymal cells what do oligodendrocytes do
