دانلود رایگان مقاله لاتین میکرو ناهمگنی مکانیکی کورتیکال استخوان از سایت الزویر
عنوان فارسی مقاله:
میکرو ناهمگنی مکانیکی و مواد معدنی از کورتیکال استخوان انسان حاکم بر فعالیت استئوکلاست
عنوان انگلیسی مقاله:
Microscale mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Bone remodeling occurs throughout life and provides the bone turnover required to adapt both structure and architecture of bone tissue to its mechanical environment. Harmonious remodeling is vital to maintain the biological and mechanical characteristics of healthy bone [1– 3]. Osteoclasts - cells of a hematopoietic origin - are one of the three main bone cell types that play a crucial role in the bone remodeling cycle [4]. Mature bone-resorbing osteoclasts adhere tightly to the bone surface at the sealing zone and dissolve both the inorganic and organic components of the bone matrix by secreting protons and enzymes [5]. This resorption phase initializes bone remodeling and thus determines the bone areas that will be substituted. Impaired osteoclast activity is involved in many bone diseases, such as osteoporosis [6] and osteogenesis imperfecta [7]. Thus, osteoclasts are prime targets in the development of new therapeutic treatments [8]. Moreover, resorption is an essential parameter in the formulation of better performing biomaterials whose bioresorbability has to be controlled [9]. Recent studies on osteoclasts have allowed for a better understanding of the mechanisms involved in the differentiation of these cells and the intracellular mechanisms that are responsible for the resorption, the regulation of the resorption process remains unclear. Particularly, the behaviour of osteoclasts and their capacity to function in a cyclic manner - alternating between resorption and migration phases - has not been fully elucidated. In this study, we postulated that the in vitro observations of these alternating resorption and migration phases are regulated by the microstructure of the support used. The resorption profile was observed, for the first time, on human cortical bone in which the heterogeneous microstructure differs from the supports that are routinely used to investigate osteoclasts in vitro. Previous in vitro studies on resorption were carried out using substrates that were either synthetic or natural - such as bovine bone or dentin. However, the osteoclast behaviour (adhesion, activity) varies according to the nature of the substrates [10,11]. For synthetic substrates, the osteoclastic activity varies according to the composition, roughness, and size of the hydroxyapatite crystals [11]. Regarding natural substrates, each has its own composition and microstructure; although their composition is similar, dentin has a tubular structure [12], whereas bovine bone is plexiform. Under the same culture conditions, the surface area of dentin resorbed by osteoclasts is 11 times larger with 7 times more pits per square centimetre than bovine bone [10]. Thus, the characteristics and organization of the material microstructures predispose them to be more or less resorbed. This observation suggests that the intracellular function of osteoclasts is modulated by the support (adhesion capacity – enzyme efficiency).
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کلمات کلیدی:
Microscale mechanical and mineral heterogeneity of human cortical ... https://www.tripdatabase.com/.../9196258-Microscale-mechanical-and-mineral-hetero... Microscale mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity. Bone, 2016. View rest of article at www.ncbi.nlm.nih.gov→. Microscale mechanical and mineral heterogeneity of human cortical ... f1000.com/prime/pubmed/ref/27725316 ... and mineral heterogeneity of human cortical bone governs osteoclast activity. ... Remodeling is carried out by a subtle equilibrium between bone formation by ... Normal Bone Anatomy and Physiology cjasn.asnjournals.org/content/3/Supplement_3/S131.full by B Clarke - 2008 - Cited by 826 - Related articles The adult human skeleton is composed of 80% cortical bone and 20% trabecular ..... Populations of osteoblasts are heterogeneous, with different osteoblasts ..... Smit TH: Strain-derived canalicular fluid flow regulates osteoclast activity in a ... Bone - Arthroscopy Journal www.arthroscopyjournal.org/article/S8756-3282(09)01565-8/references May 21, 2009 - DOI: http://dx.doi.org/10.1016/j.bone.2009.04.249 ..... mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity. Microscale mechanical and mineral heterogeneity of human cortical ... https://www.sparrho.com/...heterogeneity-of-human-cortical-bone-governs-osteoclast-... Oct 8, 2016 - Human cortical bone permanently remodels itself resulting in a haversian ... heterogeneity of human cortical bone governs osteoclast activity ☆. Bone www.fertstert.org/article/S8756-3282(12)01294-X/addons A temporary decrease in mineral density in perinatal mouse long bones .... and mineral heterogeneity of human cortical bone governs osteoclast activity. Microscale mechanical and mineral heterogeneity of human cortical ... www.sciencedirect.com.commentanypage.com/.../Microscale-mechanical-and-mineral... Nov 1, 2016 - Microscale mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity. T. Hoc a , , a LTDS UMR CNRS 5513, ...
