دانلود رایگان مقاله لاتین میتوفیوژن در اختلال میتوکندری از سایت الزویر
عنوان فارسی مقاله:
نقش وابسته MiR-195 میتوفیوژن2 در اختلال میتوکندری نورونهای هیپوکامپ در موش SAMP8
عنوان انگلیسی مقاله:
MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Alzheimer's disease (AD), a complex age-related neurodegenerative disease, is characterized by a variable degree of progressive loss of cognitive function. Although the precise mechanism of neurodegeneration in AD is not clear, there is a complex etiology is likely involved in multiple environmental, age-related, genetic, epigenetic, and inflammatory factors (Colangelo et al., 2002). Recent studies have shown that gene expression was deregulated in the hippocampus and cortex of AD patients and animal models during ageing, resulting in structural and functional damages (Liu et al., 2012; Manczak et al., 2011). Mitofusin2 (mfn2), a mitochondrial fusion protein, is expressed mainly in tissues with high energetic requirements, such as brain, skeletal muscle, and heart (Chen et al., 2004). Several lines of evidence have demonstrated that mfn2 was not only involved in the modulating of mitochondrial shape and mitochondrial metabolism but also convinced to participate in the control of proliferation and apoptosis of various cells (Bucha et al., 2015; Chen et al., 2004; Guo et al., 2007; Wang et al., 2015). In addition, mfn2 is associated with the regulation of cell cycle progression, organelle shape and autophagy (Hailey et al., 2010). Multiple studies have established a link between the deregulated expression or mutation of mfn2 with some diseases, such as diabetes, cancer, and Charcot-Marie-Tooth diseases (Gao et al., 2012; Montecchiani et al., 2016; Wang et al., 2015). Our previous studies have demonstrated that the mRNA and protein levels of mfn2 were increased in the vascular smooth muscle cells (VSMC) during the cell redifferentiation (Zhang et al., 2010). More importantly, Manczak et al. reported that mfn2 mRNA and protein levels were down-regulated in the frontal cortex brain specimens from the patients at all Braak stages of AD progression (Manczak et al., 2011). Similarly, mfn2 protein levels were decreased in neurons from hippocampus of postmortem AD patients (Wang et al., 2009) and primary hippocampal cultures from triple-transgenic (3×Tg) AD mice compared to nontransgenic (NTg) mouse neurons (Chen et al., 2016). The normal function of neurons requires mitochondrial synaptic terminals, which depending on the mitochondrial membrane dynamic properties. As one of the dynaminrelated fusion proteins, mfn2 is involved in the maintenance of the dynamic balance of mitochondrial fusion and fission (Hollenbeck and Saxton, 2005). Moreover, it has been confirmed that mfn2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration (Misko et al., 2012). The imbalance of mitochondrial fission/ fusion has also been observed in the neurodegenerative diseases, such as AD (Corrado et al., 2012; Manczak et al., 2011). These reports suggested that mfn-2 is a key functional protein with regulatory and structural nature in brain, and plays an important role in the pathogenesis of AD. However, the upstream regulatory mechanisms of mfn2, especially at posttranscriptional level, still remain unclear. MicroRNAs (miRNAs) have been implicated as important biological regulators of genes that regulate gene expression post-transcriptionally by translational repression or degradation of target mRNAs (Guo et al., 2010). It is estimated that more than one-third of all protein-coding genes are regulated by miRNAs in animals (Bartel, 2009). Although several researches have been focused on miRNA mediated regulation of mfn2 in human derived neuroblastoma cells and C2C12 myoblast (Bucha et al., 2015; Zhang et al., 2013), but there were no studies have been performed on the upstream regulation of mfn2 by miRNAs in the progression of AD.
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کلمات کلیدی:
MiR-195 dependent roles of mitofusin2 in the mitochondrial ... - ISI-dl isi-dl.com/item/97355 MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice. sciencedirect.com ... Molecular Interaction of Mitofusin 2 and Its Role in Mitochondrial ... https://books.google.com/books?isbn=1109192177 Pinwei Huang - 2008 It is also reported that mitochondrial 7+ • .... morphology also plays roles in ... and inhibition of MEK- dependent signaling pathways (Pawlikowska et al., 2007). Critical reappraisal confirms that Mitofusin 2 is an endoplasmic ... - PNAS www.pnas.org/content/113/40/11249.full.pdf by D Naon - 2016 - Cited by 27 - Related articles calling for a critical re-evaluation of Mfn2's role in ER–mitochondria cross-talk. ... Mfn2-dependent tethering is regulated by posttranslational mod- ifications: ... Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum ... www.pnas.org/content/109/14/5523.full by D Sebastián - 2012 - Cited by 207 - Related articles Apr 3, 2012 - On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering .... Mitochondrial fragmentation impairs insulin-dependent glucose ... Mitochondria: the cell powerhouse and nexus of stress: https://books.google.com/books?isbn=2889192830 Sabzali Javadov, Andrey V. Kuznetsov - 2014 - Biology (General) Role of the creatine/phosphocreatine system in the regulation of ... of multiple organ abnormalities in an age-dependent and organ-specific manner. ... Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic ... - PNAS www.pnas.org/content/113/40/11249?tab=related Oct 4, 2016 - On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria ... reticulum regulates apoptosis in a Ca2+-dependent manner PNAS 2015 ... BCL‐2 Protein Family: Essential Regulators of Cell Death https://books.google.com/books?isbn=1441967060 Claudio Hetz - 2011 - Medical The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. ... its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. ... Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax ... Cell Death and Differentiation - Sirtuin 1 suppresses mitochondrial ... www.nature.com › Journal home › Archive › Original Papers by TG Biel - 2016 - Cited by 15 - Related articles Jul 17, 2015 - ... dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner ... The role of Sirtuin 1 (SIRT1) in hepatic I/R injury remains elusive.
