دانلود رایگان مقاله لاتین مخاط حلزون در ویروس سرخک از سایت الزویر
عنوان فارسی مقاله:
اثر ضد ویروس مخاط حلزون در ویروس سرخک
عنوان انگلیسی مقاله:
The antiviral effect of mollusk mucus on measles virus
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Measles virus (MV) is one of the most infectious microorganisms known and continues to cause extensive morbidity and mortality worldwide. Despite vaccine availability and the initiative launched by WHO, UNICEF, and their partners to increase vaccine coverage, MV has not been eradicated and has caused 140,000 deaths globally as recently in 2010 (Simons et al., 2012), making it one of the top causes of death among the vaccine-preventable diseases. MV infection causes an acute febrile respiratory illness with skin rash and may cause acute, profound suppression of the immune system. The neurological sequelae of measles can occur within days to years after acute infection, often resulting in severe disability and death (Hosoya, 2006). Acute post-infectious encephalomyelitis occurs primarily in older children and adults during or shortly after acute infection. Subacute sclerosing panencephalitis (SSPE) is a late neurodegenerative complication associated with the persistent infection of brain cells (Bale, 2014). Veronicellidae are hermaphroditic mollusks that can perform cross-fertilization/self-fertilization. Phyllocaulis boraceiensis has a long and single period of reproduction between July and September (Toledo-Piza et al., 2012, 2013). P. boraceiensis mucus is an exudate that acts as the animal's defense system. Terrestrial slugs and snails produce mucus which performs a variety of functions, including facilitating movement along the ground, communication and a non-specific, defensive response to physical or chemical irritation. This material is a mucoprotein that “in natura” appears highly viscous; it contains 600 mg/mL glucose, 6.9 105 mg/mL lipids and 1.15 104 mg/mL of protein and aminoacid residues (Toledo-Piza et al., 2012). A study on the effect of Phyllocaulis boraceiensis mucus in the induction of fibroblast proliferation, demonstrated an increase of *over 50% in the number of cells when compared to the control experiment (Toledo-Piza et al., 2013). This same material was also able to induce angiogenesis in co-cultured endothelial cells and fibroblasts (Toledo-Piza and Maria, 2013). The biological activity of this mucus was also shown by enhanced dermal healing in mice submitted to a dorsal incision and treated daily with 100 mL of P. boraceiensis mucus. A reduced wound closure time was observed in mice treated with anointment containing 0.012 mg/mL mucus. Tissue remodelling began after four days of treatment and showed redness, edema and bleeding until the 5th day post-surgery. Granulation and healing tissue appeared intensely from the 11th day (Toledo-Piza and Maria, 2014). There are no specific therapies for acute complications of MV or for persistent MV infections. Therefore, the search for new antiviral compounds is important due to the specific needs of immune compromised people at risk for MV infection, who cannot be vaccinated or do not respond adequately to vaccines. Many studies have shown the importance of invertebrates, with an emphasis on mollusks, in the search for new antiviral compounds. Leading in consideration, the importance of active compounds extracted from invertebrates, our research group proposed to study Phyllocaulis boraceiensis mucus as a source of bioactive molecules with antiviral activity in MV cultures.
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کلمات کلیدی:
Article: The antiviral effect of mollusk mucus on measles virus ... https://manuscriptpro.com/.../The-antiviral-effect-of-mollusk-mucus-on-measles-virus... Author Ana Rita de Toledo-Piza (Laboratory of Parasitology, Butantan Institute, 1500th, Vital Brazil Ave, São Paulo, SP, Brazil. Electronic address artpiza at ... 1. The antiviral effect of mollusk mucus on measles virus - 首页 en.ustc.findplus.cn/?h=articles&db=edselc&an=edselc.2-52... - Translate this page Title: The antiviral effect of mollusk mucus on measles virus. Authors: Toledo-Piza, A.R.D.1. Tonelotto, M.1. Villar, K.D.S.1. Rofatto, H.K.1. Mendonça, R.Z.1 Skin Infections: Diagnosis and Treatment https://books.google.com/books?isbn=0521897297 John C. Hall, Brian J. Hall - 2009 - Medical ... 296 RNA retroviruses, 284 HIV, 284 human T-lymphotropic virus, 284 RNA ... 291—292 mumps in mucous membrane infections, 283 ProQuad vaccine for, 278 ... 202—203 treatment, 23 mollusks and aquatic dermatoses, 174 monkeypox, ... Proliferation of fibroblasts and endothelial cells is enhanced by ... onlinelibrary.wiley.com/doi/10.1111/cpr.12003/abstract by AR Toledo‐Piza - 2013 - Cited by 7 - Related articles Dec 21, 2012 - Abstract. Previously, mucus of some molluscs has been studied as a potential source of new natural compounds capable of inducing cell ... Exploring Life Science https://books.google.com/books?isbn=0761471359 2000 - Life sciences ... marine Ofth e ocean. mass Amount of matter. measles Viral disease causing a ... molecule Stable arrangement of two or more atoms. mollusk Unsegmented, ... in plants containing sugars and proteins. mucus (MYEW-kuhs) Slimy liquid, ... The Elements of Immunology - Page 467 - Google Books Result https://books.google.com/books?isbn=8131711587 Fahim Halim Khan - 2009 - Immunology molluscs, 20 Molluscum contagiosum virus (poxvirus), 321 monoclonal ... mucosal mast cells (MMC), 270 mucous membrane, 4-5 multi-lineage-CSF (multi-CSF or ... MC159.321 measles virus, 216 mechanical/physical barrier, of immunity, 4-5 ...
