دانلود رایگان مقاله لاتین سنسور گلوکز فیبر نوری از سایت الزویر
عنوان فارسی مقاله:
کمپلکس هیدروژل با گود بی حرکت مغناطیسی برای سنسور گلوکز فیبر نوری کنترل دما
عنوان انگلیسی مقاله:
Complex of hydrogel with magnetic immobilized GOD for temperature controlling fiber optic glucose sensor
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Glucose is very important for the life cycles but the high level of glucose in blood could cause diabetes. In recent years, more and more people around the world are suffering from the long-term risks of diabetes complications, such as heart disease, cardiovascular diseases and blindness [1,2]. Therefore, it is very urgent to develop a fast, reliable and economic method for the determination of blood glucose concentration. Over the last few decades, many methods have been developed to detect glucose, including high performance liquid chromatography (HPLC) [3,4], colorimetry [5], spectrophotometry [6], chemiluminescence [7,8], electrode [9–11], electrochemical sensor [12,13], quantum dots sensing [14–16] and optical sensing [17–19]. Fiber optic biosensors have many advantages compared with electrical sensors and electrochemical sensors [20]. As a branch of fiberoptic sensors, the enzyme based fiber optic biosensors have great application potential in many fields and will be an effective way to detect glucose. If the enzyme performance can be controlled, the detection of glucose by the enzyme based fiber optic biosensors can be controlled, which will have important applications in many cases. Stimuli-sensitive hydrogels have tunable three-dimensional physical network structures and good biocompatibility [21]. Their volumes will change with a slight variation of external stimuli, such as temperature, light, chemical environment, etc [22]. Thermosensitive hydrogels have a lower critical solution temperature (LCST), and will swell at the temperature lower than LCST and shrink at the temperature higher than LCST. Because of this characteristic, hydrogels have been extensively used as the carriers for the temperature controlled release of macromolecular drugs [23–25]. Poly(N-isopropylacrylamide) (PNIPAAm) is a well known temperature sensitive polymer with a LCST of ∼32 ◦C in aqueous solution [26]. The introduction of segment acrylamide (AAm)to the PNIPAAm could form Poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAAm-co-AAm)), which could slightly increase its LCST [23] and made the LCST close to human body temperature. If P(NIPAAmco-AAm) is used to form a complex with enzyme, the hydrogel will shrink at the temperature higher than its LCST and the enzyme is isolated from the substrate, which will cause the enzymatic catalysis reaction to stop. On the other hand, when the temperature is lower than its LCST, the hydrogel will swell, which allows the enzyme to have contact with the substrate and cause the enzymatic catalysis reaction to take place. Therefore,the enzyme performance can be controlled by changing the temperature. This kind of complex materials can be used for the fiber optic biosensor to perform controllable detection, and also for multi parameters fiber optic biosensors which can detect different species such as glucose and cholesterol at different temperature. In our previous work [27], the magnetic fluorescent coreshell structured Fe3O4@SiO2(F)-@meso-SiO2 nanoparticles were prepared. Cholesterol oxidase (COD) was immobilized on their surface and immobilization conditions were investigated and optimized. In this work, Glucose oxidase (GOD) was immobilized on Fe3O4@SiO2(F)@meso-SiO2 nanoparticles using the similar method [27]. P(NIPAAm-co-AAm) was combined with magnetic immobilized GOD to formP(NIPAAm-co-AAm)-magnetic immobilized GOD complex (PMIGC) using in-situ complex method. The immobilizationof GOD willimprove the enzyme stability and thenanoparticles with the magnetic core will be beneficial to the isolation of the immobilized enzyme from the reaction mixture. By changing temperature, the oxidation of glucose was controlled using PMIGC as the catalyzer. Using lock-in technology, a fiber optic glucose sensor based on PMIGC was fabricated to perform the controllable detection of glucose and the sensor properties were studied. The sensor can detect glucose effectively, indicating a promising prospect of practical application. To the best of our knowledge,there have been no publications on this temperature controlling fiber optic glucose biosensor based on PMIGC.
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کلمات کلیدی:
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