دانلود رایگان مقاله لاتین تشکیل پروتئین پیچیده در سلول سرطان از سایت الزویر
عنوان فارسی مقاله:
تشکیل پروتئین های پیچیده و پویایی اینترانوکلیر NAC1 در سلول های سرطانی
عنوان انگلیسی مقاله:
Protein complex formation and intranuclear dynamics of NAC1 in cancer cells
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Nucleus accumbens-associated protein 1 (NAC1), encoded by the NACC1 gene, is a nuclear protein that harbors an N-terminal BTB/POZ (broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger) (hereafter abbreviated BTB) and a C-terminal BEN (BANP, E5R and NAC1) domain (Fig. 1A). The BTB domain is a ~100 amino acid highly conserved motif that mediates homodimerization and/ or heterodimerization and interacts with other proteins [1,2]. NAC1 homodimerizes through its BTB domain [3] and heterodimerizes with Myc-interacting zinc-finger protein 1 (Miz1) through the respective BTB domain [4,5]. Most BTB proteins contain other Cterminal functional domains, such as DNA-binding zinc fingers. NAC1 lacks these characteristic DNA-binding domains but instead contains a C-terminal BEN domain, identified through computational analysis in 2008, which may mediate protein-DNA and protein-protein interactions [6]. NAC1 participates in various biological processes. NAC1 was originally identified and cloned as a cocaine-inducible transcript from the nucleus accumbens, a unique forebrain structure involved in reward motivation and addictive behavior [7]. NAC1 is known to be important for the pluripotency of embryonic stem cells [8,9]. Recently, NAC1 was shown to promote mesendodermal and repress neuroectodermal fate selection in embryonic stem cells, in cooperation with other pluripotency transcription factors, Oct4, Sox2, and Tcf3 [10]. NACC1 knockout mouse embryos and newborns exhibit a lower survival rate for embryos or newborns, with surviving mice showing defective bony patterning in the vertebral axis [11]. NACC1 was also identified as a cancer-associated BTB gene by serial analysis of gene expression in ovarian cancer cells [12]. NAC1 is significantly overexpressed in several types of carcinomas including ovarian, colorectal, breast, renal cell, cervical, and pancreatic carcinomas is associated with tumor growth and survival, and increases the resistance of tumor cells to chemotherapy [12e22]. These reports suggested that NAC1 plays a driver role in cancer development and that it might be a potential therapeutic target.
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کلمات کلیدی:
Protein complex formation and intranuclear dynamics of NAC1 in ... www.bioportfolio.com › Topics › Nutrition › Research Jul 13, 2016 - ... that NAC1 may be a potential therapeutic target, but protein complex formation and the dynamics of intranuclear NAC1 in cancer cells remain ... Protein complex formation and intranuclear dynamics of NAC1 in ... - خانه zoodyab.ir/.../115429-protein-complex-formation-and-intranuclear... Translate this page Sep 15, 2016 - NAC1 is overexpressed in various carcinomas including ovarian, cervical, ... formation and the dynamics of intranuclear NAC1 in cancer cells ... Cell Cycle Dependent Alteration in NAC1 Nuclear Body Dynamics and ... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164573/ by PH Wu - 2011 - Cited by 13 - Related articles Feb 7, 2011 - Cell Cycle Dependent Alteration in NAC1 Nuclear Body Dynamics and Morphology. Pei-Hsun Wu, Shen-Hsiu Hung, [...], and Yiider Tseng. Effect of Estradiol on Histone Acetylation Dynamics in Human Breast ... www.jbc.org/content/276/52/49435.full by JM Sun - 2001 - Cited by 67 - Related articles Dec 28, 2001 - However, estradiol did alter the intranuclear distribution of ER and histone .... T5 cells were resuspended in TNM buffer (100 mm NaCl, 300 mm sucrose, ... This study was repeated with the human breast cancer cell line MDA ... G196 epitope tag system: a novel monoclonal antibody, G196 ... - Nature https://www.nature.com › Scientific Reports › Articles Mar 7, 2017 - HeLa cells were transfected with FHG-G196-NAC1/pcDNA3. ..... Protein complex formation and intranuclear dynamics of NAC1 in cancer cells . nac1 nuclear bodies: Topics by Science.gov https://www.science.gov/topicpages/n/nac1+nuclear+bodies.html Cell cycle-dependent alteration in NAC1 nuclear body dynamics and ..... Protein complex formation and intranuclear dynamics of NAC1 in cancer cells. PubMed.
