دانلود رایگان مقاله لاتین اوستیومالاسیا ناشی از دیپیوکسیل از سایت الزویر
عنوان فارسی مقاله:
اوستیومالاسیا ناشی از دیپیوکسیل طولانی مدت با دوز پایین آدفوویر: ویژگی های بالینی و پیش بینی های ژنتیکی
عنوان انگلیسی مقاله:
Osteomalacia induced by long-term low-dose adefovir dipivoxil: Clinical characteristics and genetic predictors
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The rapid development of antiviral drugs has considerably reduced the mortality of chronic hepatitis B patients. Adefovir dipivoxil (ADV), a type of nucleotide analogue developed in 2002, is extensively used for chronic hepatitis B therapy. ADV has high antiviral activity [1,2] and efficacy. However, ADV may be associated with potentially serious nephrotoxicity, which could induce secondary hypophosphatemic osteomalacia. Preliminary studies revealed that significant nephrotoxicity occurs at a high dosage (N30 mg once daily) [3,4]. To date, clinical studies have rarely reported severe nephrotoxicity in patients treated with ADV at a low dosage (10 mg once daily). Thus, the nephrotoxicity associated with ADV may be dose-limiting. Nevertheless, the long-term clinical application of ADV at a conventional dosage has been found to be responsible for proximal renal tubular dysfunction and secondary hypophosphatemic osteomalacia [5–10]. Here, we report our findings from the study of 76 patients who developed hypophosphatemic osteomalacia secondary to ADV use. The mechanism by which ADV causes renal tubular dysfunction is not well understood, although transporter proteins in the renal tubule may be involved. The nucleoside analogue enters the epithelial cells of the proximal tubule through the basolateral membrane and utilizes organic anion transporters (OATs), mainly OAT1 (encoded by the solute carrier gene SLC22A6) [11–13]. The drug is then secreted into the urine through the luminal membrane utilizing multidrug-resistance proteins (MRPs), primarily MRP2 (encoded by adenosine triphosphate-binding cassette sub-family C gene ABCC2) [12–14]. For many antiviral drugs, the efflux at the luminal membrane is rate limiting and occasionally results in intracellular accumulation [15]. Therefore, transporter expression may modulate the extent of tubular damage. To further explore the mechanism, we investigated the association between polymorphisms in the ABCC2 and SLC22A6 genes and the development of tubular dysfunction in chronic hepatitis B patients treated with ADV.
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کلمات کلیدی:
Osteomalacia and Fanconi's syndrome caused by long& ... onlinelibrary.wiley.com/doi/10.1111/jcpt.12259/pdf Feb 5, 2015 - Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil. B.-F. Wang* MD, Y. Wang† MD, B.-Y. Wang* MD, F.-R. Hypophosphatemic osteomalacia induced by low-dose adefovir therapy link.springer.com/article/10.1007/s00774-012-0384-y by DH Kim - 2013 - Cited by 30 - Related articles Large clinical studies of low-dose adefovir dipivoxil (adefovir) have found no ... cases of low-dose adefovir-induced hypophosphatemic osteomalacia that initially ... Fanconi syndrome due to prolonged use of low-dose adefovir pubmedcentralcanada.ca/pmcc/articles/PMC4468461/ by XB Wang - 2015 - Cited by 5 - Related articles Fanconi syndrome due to prolonged use of low-dose adefovir .... fracture associated with osteomalacia induced by low-dose ADV treatment. .... Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: A randomized controlled trial. Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced ... pubmedcentralcanada.ca/pmcc/articles/PMC4870331/ by YS Lee - 2016 - Cited by 2 - Related articles May 10, 2016 - In Fanconi syndrome, hypophosphatemic osteomalacia is caused by ... Keywords: Chronic hepatitis B, Adefovir dipivoxil, Fanconi syndrome, ... However, a report of pathologic fracture induced by low dose ADV therapy is rare. [PDF]Fanconi syndrome due to prolonged use of low-dose adefovir www.jrms.mui.ac.ir/files/journals/1/articles/10209/public/10209-39041-1-PB.pdf by XB Wang - 2015 - Cited by 5 - Related articles He had a 7-year history of chronic hepatitis caused by ... prolonged low-dose (10 mg daily) ADV therapy. C ase. R .... associated with osteomalacia induced by low-dose ADV .... Fanconi's syndrome associated with prolonged adefovir dipivoxil. Adefovir dipivoxil-induced development of osteomalacia and Fanconi ... https://journals.edizioniseed.it/index.php/cmi/article/view/969/1176 by O Staltari - 2014 - Related articles Keywords: Adefovir dipivoxil; Osteomalacia; Fanconi syndrome; HBV; Cirrhosis ..... syndrome and renal failure caused by long-term low-dose adefovir dipivoxil.
