دانلود رایگان مقاله لاتین الکتروریسی پلیمر پلی آنیلین پپتید از سایت الزویر
عنوان فارسی مقاله:
تلفیق، شناسایی و الکتروریسی پلیمرهای پلی آنیلین پپتید جدید
عنوان انگلیسی مقاله:
Synthesis, characterization, and electrospinning of novel polyaniline–peptide polymers
سال انتشار : 2016
برای دانلود رایگان مقاله الکتروریسی پلیمر پلی آنیلین پپتید اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
Synthetic polymers, such as polyaniline, polyethylene oxide, and polyethylene glycol, have often been used as matrixes for immobilization of proteins and peptides for catalytic, sensoring, synthetic, or therapeutic purposes [1–3]. While quite useful in many cases, these type of devices often have limited working range restricted by the solubility, structural stability, and pH sensitivity of the components. The search for more effective ways to achieve a synergistic combination of properties leads to the development of protein–polymer conjugates [4–7]. Synthetic strategiesinclude utilization of common chemical reactions (Heck, Suzuki coupling, cycloaddition reactions) [8–10] with polymer-reactive peptides/proteins, or protein/peptide reactive polymers, under mild conditions, in order to render a product with the desired structure and properties. Modification of proteins and peptides occurs through the accessible amino acids and reactions may take place with the carboxyl and amino function as well as with the amino acid side chain [11,12]. Polyaniline, a conductive polymer subject to numerous studies because of easy synthesis, tunable properties, and plenty of potential practical applications, can also be obtained in chiral form in presence of chiral inducers [13–15]. Chiral PANI can be obtained by chemical, electrochemical, or enzymatic polymerization as well as by chiral doping-dedoping procedure [16–18]. Chiral acids, such as (+) or (−) 10-camphorsulphonic acid, have successfully induced chirality in the PANI polymer chains, however DNA, polysaccharide, and cellulose, have never been used for this purpose [19]. From another side, studies have shown that proteins, peptides, and even amino acids, present in the polymerization reaction mixture, can induce chirality and selective recognition sites. Polymerization of aniline monomers in presence of hemoglobin or bovine serum albumin, on DBSA template under mild conditions, produce enantio specificity of PANI probably due to the -helical structure ofthe proteins [15]. PANI obtained from saturated solutions of lphenylalanine, using ammonium persulfate as an oxidant, results in chiral PANI of flaky, spherical, and urchin-like morphologies. The latter research assumes also that l-phenylalanine is incorporated in the PANI chains as a dopant [20]. Electrospinning has been utilized to produce fiber mats with various sizes and properties. Polyaniline is notoriously difficult to electrospin since its low solubility in common solvents prevents the formation of solutions with appropriate concentration and viscosity [21]. De-doping with substances, such as camphorsulfonic acid, increases the solubility, however, electrospinning has been reported only in presence of supporting polymers [21–23]. We have previously reported an investigation on the attachment of dioxin selective pentapeptides on polyaniline matrix with or without a linker, and the stability of the chemosensors under different conditions [24]. Some of the peptides used in the study have been previously reported to selectively bind chlorinated toxins [25,26]. The objectives of this research are the following: (1) to explore the chemical and electrochemical polymerization of aniline in presence of penta- and hexapeptides FLDQV, FLDQVC, as well as their Dansyl and AMC labeled derivatives. (2) To produce electrospun fibers from the PANI–peptide polymers and the compare the results with the PANI-CSA doped electrospun mats. (3) To perform preliminary testing of the polymers and the fibers for extraction of chlorinated toxins. Our hypothesis is that the PANI–peptide polymers and fibers will be promising binding reagents which can be further utilized as solid state extraction tools.
برای دانلود رایگان مقاله الکتروریسی پلیمر پلی آنیلین پپتید اینجا کلیک نمایید.
کلمات کلیدی:
Polymers | Free Full-Text | Nanomembranes and Nanofibers from ... www.mdpi.com/2073-4360/5/3/1115/htm by E Llorens - 2013 - Cited by 30 - Related articles Sep 17, 2013 - Electrospinning of some polymers may be problematic but in some cases ... Development of Novel Biodegradable Samples Having Aniline Units ... Hence covalent grafting of bioactive molecules, such as adhesion peptides, ... [PDF]Electro-Active Polymers (EAPs): A Promising Route to Design Bio ... www.mdpi.com/2073-4360/8/5/185/pdf by V Guarino - 2016 - Cited by 4 - Related articles May 9, 2016 - Despite several novel conducting polymers with selected monomer inclusions are ... that PPy can alter protein adsorption as a function of the dopant anion and .... peculiar interaction between doped polyaniline and polymer matrix allows ... electrospinning where electric forces strongly interact with polar ... Oligomer-Assisted Synthesis of Chiral Polyaniline Nanofibers ... pubs.acs.org/doi/full/10.1021/ja039672q by W Li - 2004 - Cited by 279 - Related articles Feb 6, 2004 - Electrospinning from polymer melts in a vacuum is advantageous because ..... and electrospinning of novel polyaniline–peptide polymers. Nanostructured Conductive Polymers - Google Books Result https://books.google.com/books?isbn=1119956544 Ali Eftekhari - 2011 - Technology & Engineering The same group also studied the conducting polymer, polyaniline (PANI), as a novel electrically conductive ... adhesive peptides onto the surface of prefabricated conducting polymer films or into ... The work of Li et al. describes the approaches of covalently attaching oligopeptides to PANI and electrospinning PANI-gelatin ... Protein-Induced Synthesis of Chiral Conducting Polyaniline ... pubs.acs.org/doi/abs/10.1021/mz500008f by H Guo - 2014 - Cited by 10 - Related articles Mar 11, 2014 - A green and novel method for the synthesis of chiral conducting polyaniline was ... and electrospinning of novel polyaniline–peptide polymers. Biomedical Applications of Polymeric Nanofibers https://books.google.com/books?isbn=3642271480 Rangasamy Jayakumar, Shantikumar Nair - 2012 - Technology & Engineering ... Synthesis and characterization of a novel biodegradable antimicrobial polymer. ... on electrospun polyurethane scaffolds decreases atrial natriuretic peptide ... ID et al (2000) Electrostatic fabrication of ultrafine conducting fibers: polyaniline/ ...
