دانلود رایگان مقاله لاتین اختلال کارکردی تیروئید و ناباروری از سایت الزویر
عنوان فارسی مقاله:
اختلال عملکرد تیروئید و ناباروری
عنوان انگلیسی مقاله:
Thyroid dysfunction and subfertility
سال انتشار : 2015
بخشی از مقاله انگلیسی:
Thyroid hormone disorders and subfertility
Overt hyperthyroidism results in the alteration of estradiol metabolism and the augmentation of gonadotropin in response to gonadotropin-releasing hormone. Baseline gonadotropin concentrations are also frequently elevated. The current prevalence of irregular cycles is 21.5%, which is a dramatic decrease from the previously reported figure of 65%, due to the earlier detection and treatment of hyperthyroidism . These features become normalized after the administration of antithyroid drugs. Studies on the prevalence of subfertility in women with hyperthyroidism are limited. Moreover, most such studies are uncontrolled, retrospective, and small in size. The prevalence of primary or secondary infertility associated with hyperthyroidism has been described to be 0.9% to 5.8% [6,7]. Nonetheless, the exact impact of hyperthyroidism on fertility remains ill-defined. Hypothyroidism has been associated with altered ovulatory function, menstrual irregularities, subfertility, and higher (recurrent) miscarriage rates. Usually, treatment corrects these problems. More recent studies have reported a lower frequency of menstrual abnormalities . Subclinical hypothyroidism (SCH) is defined by an increase in serum TSH concentrations with normal free thyroxine (FT4) levels. The prevalence of SCH in subfertile women has been reported to vary from 0.7% to 43% . The wide range of prevalence is due to the differences in sensitivity of serum TSH measurement. The revised clinical practice guidelines of the Endocrine Society recommend the measurement of serum TSH in order to screen for thyroid dysfunction in women over the age of 30 years with infertility or a prior history of miscarriage . The data are insufficient to conclude that SCH is clearly associated with subfertility. However, some investigators have suggested that SCH may be associated with subfertility. In one study of 509 subfertile women planning an in vitro fertilization cycle, TSH levels were significantly higher among women who produced oocytes that failed to be fertilized (mean, 5.1 μIU/mL) . In clinical practice guidelines for hypothyroidism in adults, the American Association of Clinical Endocrinologists (AACE) and the American Thyroid Association (ATA) have recommended that treatment with L-thyroxine should be considered in women of childbearing age with SCH when they are planning a pregnancy . Two small randomized trials have evaluated whether the administration of L-thyroxine for SCH improved pregnancy outcomes in in vitro fertilization cycles. These studies found that the miscarriage rate was significantly lower in the L-thyroxine group than in the placebo group, while the clinical pregnancy rate and delivery rate were both significantly higher [13,14].
Thyroid Disease, Pregnancy & Fertility - Thyroid Foundation of Canada www.thyroid.ca/pregnancy_fertility.php Health Guides on Thyroid Disease. Thyroid Disease, Pregnancy and Fertility. Thyroid disease is not common during pregnancy. This is because the immune system, which plays a role in thyroid disease, is suppressed during pregnancy in order to protect the developing fetus. As a result of the loss of this protective effect at ... Female infertility and the thyroid - ScienceDirect www.sciencedirect.com/science/article/pii/S1521690X04000144 Thyroid dysfunction adversely affects fertility. Many studies imply a role for immunology, including thyroid autoimmunity in conception failure. In this review we attempt to update the available information on the adverse effect of thyroid dysfunction and/or thyroid autoimmunity on subfertility and we propose a rationale for ... Infertility, Miscarriage, and Subclinical Hypothyroidism | Hypothyroid ... https://hypothyroidmom.com/infertility-miscarriage-and-subclinical-hypothyroidism/ Aug 14, 2014 - I wish more than anything I had found a good thyroid doctor before I miscarried my baby unnecessarily to hypothyroidism. My child may be alive today. I hope this article by New York City reproductive endocrinologist Dr. Hugh Melnick finds all the women struggling with infertility and miscarriage.