دانلود رایگان مقاله لاتین اثر ضد آندروژن دراستفاده نامناسب ترابکولار از سایت الزویر
عنوان فارسی مقاله:
اثرات ضد آندروژن ها دراستفاده نامناسب ترابکولار مستقل استئوپنی از آتروفی عضلانی
عنوان انگلیسی مقاله:
Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Androgens are sex steroid hormones which act via the androgen receptor (AR) on bone and muscle cells [1,2]. Testosterone (T), the principal circulating androgen, can activate AR directly or following conversion to dihydrotestosterone (DHT). T can also be aromatized into estrogens (whereas DHT cannot) to regulate male bone homeostasis, mainly via estrogen receptor α (ERα) [2,3]. Over the last decade, the target cells of androgen actions on the musculoskeletal system have been investigated in AR knock-out (ARKO) mouse models using Cre/ LoxP technology [4,5]. These studies have shown that the antiresorptive effects of androgens on trabecular bone as seen in ubiquitous ARKO mice are recapitulated by conditional deletion of AR in the early osteoblast lineage, with some contribution from AR in late osteoblasts and osteocytes but not from AR in osteoclasts [3,6–10]. The effects of T on endosteal resorption on the other hand are mediated via aromatization while the target cell(s) for androgen actions on periosteal bone formation remains elusive [2,3,11]. The anabolic effects of androgens on muscle are well known in humans [12,13]. There is considerable interest in the use of T therapy in aging men, although this carries a risk of side-effects such as cardiovascular events, polycythemia and stimulation of prostate tissue. There is also growing realization that muscle may have indirect effects on bone via muscle-bone interactions [1,14]. Because androgens like T have effects on both muscle and bone, they are theoretically an appealing strategy for the combination of disuse osteoporosis and sarcopenia [14,15]. Furthermore, low serum T concentrations are often seen in situations of acute disuse [16–21]. However, whether muscle AR has direct effects on bone has not yet been reported. A better understanding of the target cells and underlying mechanisms of the beneficial effects of androgens is required to inform their appropriate use and to design alternative therapies which avoid their potential side-effects e.g. on the prostate and cardiovascular system [22,23].
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کلمات کلیدی:
Androgens have antiresorptive effects on trabecular disuse ... www.pubtransformer.com/Pubmed?pmid=27622887 Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy. Abstract, Aging hypogonadal men are at increased ... Testosterone Dose Dependently Prevents Bone and Muscle Loss in ... online.liebertpub.com/doi/abs/10.1089/neu.2013.3155 by JF Yarrow - 2014 - Cited by 16 - Related articles Dec 30, 2013 - Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy. Michaël R. Laurent , Ferran Jardí ... Androgens have antiresorptive effects on trabecular disuse ... - infona.pl https://www.infona.pl/resource/bwmeta1.element.elsevier-d623aec4.../disciplines Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy. Michaël R. Laurent, Ferran Jardí, Vanessa Dubois, ... Laurent M[au] - PubMed Result erspublications.com/lookup/external-ref?access_num=Laurent%20M&link_type... ... Vanderschueren D. Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy. Bone. 2016 Dec;93:33-42. doi: ... [PDF]Genetic and hormonal roles in bone disorders - International Society ... ismni.org/jmni/pdf/12/02FROST.pdf by HM Frost - Cited by 15 - Related articles Mar 22, 2003 - Trabeculae mainly transfer loads back and forth between ... Due to lack of study, how genes and hormones affect .... independent mechanisms for affecting whole-bone strength ..... strength, so a disuse-pattern osteopenia would develop. (iii) ..... often called antiresorption agents, estrogen and bisphospho-. colwiz | Progress in understanding disuse osteopenia - publication https://www.colwiz.com/public/.../progress_in_understanding_disuse_osteopenia%3A Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy. Laurent Michaël R, Jardí Ferran, Dubois Vanessa, ... JCI - Citations to Estrogen receptor-α signaling in osteoblast ... https://www.jci.org/articles/view/65910/citations Multifarious effects of 17-β-estradiol on apolipoprotein E receptors gene ... Androgens have antiresorptive effects on trabecular disuse osteopenia independent ...
