دانلود رایگان مقاله لاتین اثر استئاتوهپاتیت غیر الکلی از سایت الزویر
عنوان فارسی مقاله:
اثر استئاتوهپاتیت غیر الکلی در فیلتراسیون کلیوی و ترشح آدفوویر
عنوان انگلیسی مقاله:
Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Adefovir, an acyclic nucleotide reverse transcriptase inhibitor, is approved for the therapy of chronic hepatitis B, in adults with permanently increased serum alanine transaminase (ALT) activity, and histological evidence of active liver inflammation and fibrosis [1,2]. In addition to significant clinical efficacy against HBV infection, adefovir can be used during decompensated liver disease because it is dependent upon the renal processes of glomerular filtration and active tubular secretion for elimination [3,4]. However, it is now clear that liver impairment is associated with changes in glomerular filtration [5], which may create predisposition for unpredictable pharmacokinetic behavior of compounds, and sensitize the liver for further impairment. Within the course of adefovir therapy, such problems may be anticipated because patients with decompensated liver disease have higher incidence of increased serum levels of creatinine, a marker of glomerular filtration [6,7]. Nonalcoholic fatty liver disease (NAFLD) and its late stage, nonalcoholic steatohepatitis (NASH), contribute to increased sensitization of the liver to noxious stimuli [8]. Although Wang et al. [9] assert in their recent systemic review that chronic HBV infection protects against fatty liver, it has also been suggested that metabolic syndrome (largely associated with NAFLD) accelerates the progression of NAFLD to NASH in patients with HBV [10]. This suggests a possible overlap between patients with NASH and those taking adefovir chronically for HBV infection. This may be problematic, as NASH is also associated with misregulation of excretory mechanisms for many drugs. The remodeling of hepatic transport processes in NASH has been well characterized over the last several years, both in the human disease and in a variety of rodent models [11,12]. While several OATP uptake transporters are downregulated at basolateral membranes of hepatocytes [13], principal efflux transporters for anionic drugs are altered both at the basolateral (MRP3/4) and canalicular (MRP2/BCRP) membranes of hepatocytes to favor plasma retention for many substrates [11,14–16]. These alterations are also documented in a variety of genetic and dietary models of NASH [12], many of which also exhibit regulatory changes in prominent renal transporters [17]. To date, very little is known regarding the changes in renal transporter expression in human NASH, and the functional consequence to the pharmacokinetics and potential for toxicity of many drugs.
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کلمات کلیدی:
Control of Urine Oxalate Excretion - Kidney Stone Evaluation And ... kidneystones.uchicago.edu/control-of-urine-oxalate-excretion/ What enters the urine is the sum of oxalate filtered by the kidneys (the product of the glomerular filtration rate and the concentration of oxalate in blood that can ... Anika Dzierlenga | LinkedIn https://www.linkedin.com/in/anika-dzierlenga-98357867 Raleigh-Durham, North Carolina Area - IRTA Postdoctoral Fellow, National Toxicology Program - Division of the National Toxicology Program, NIEHS, NIH This study demonstrates changes to glomerular filtration and tubular secretion that alter pharmacokinetics of adefovir in nonalcoholic steatohepatitis. Guyton and Hall Textbook of Medical Physiology https://books.google.com/books?isbn=1455770051 John Edward Hall - 2015 - Medical ... 898 Nitrate, for angina pectoris, 269 Nitric oxide glomerular filtration rate and, 342 ... 72 Nonalcoholic fatty liver disease, 881-882 Nonalcoholic steatohepatitis, ... 420 anion gap and, 426 Norepinephrine, 505 adrenal medullae secretion of, ... Nutrition in Pediatrics: Basic Science, Clinical Applications https://books.google.com/books?isbn=1550093614 Christopher Duggan, John B. Watkins, W. Allan Walker - 2008 - Health & Fitness Obesity may also affect systemic clearance of highly extracted drugs such as ... lized procainamide/2 Both glomerular filtration and tubular secretion also appear to ... nonalcoholic steatohepatitis (NASH),34 including enhanced glucuronidation ... Cherrington NJ[au] - PubMed Result - Drug Metabolism & Disposition dmd.aspetjournals.org/external-ref?access_num=Cherrington%20NJ&link_type... Metabolomic profiling distinction of human nonalcoholic fatty liver disease ... Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.
