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عنوان فارسی مقاله:

IPMK: رگولاتور همه کاره حوادث علامت دهی هسته ای


عنوان انگلیسی مقاله:

IPMK: A versatile regulator of nuclear signaling events


سال انتشار : 2015



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مقدمه انگلیسی مقاله:

1. Introduction

Inositol phosphates are signaling messengers that are involved in mediating diverse biological events such as growth, proliferation, and metabolic homeostasis (Chakraborty et al., 2010; Hatch and York, 2010; Wilson et al., 2013; Shears, 2015). Inositol polyphosphate multikinase (IPMK) is an enzyme essential for the synthesis of IP4 [both Ins(1,3,4,5)P4 and Ins(1,4,5,6) P4] and IP5 [Ins(1,3,4,5,6)P5] (Saiardi et al., 1999; Frederick et al., 2005) (Fig. 1). The 6-kinase activity of IPMK makes this enzyme the sole factor capable of converting IP3 into Ins(1,4,5,6)P4 (one of only two IP4 molecules). IPMK is also the only enzyme that can produce IP5, placing it upstream of both the inositol hexakisphosphate kinases (IP6Ks) and the diphosphoinositol pentakisphosphate kinases (PPIP5Ks). IPMK depletion nearly eliminates intracellular IP6 as well as inositol



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